Publications by authors named "Ryan Hillary"
Article Synopsis
- * The study analyzed over 6,000 NT1 cases and identified new genetic associations (e.g., CD207, NAB1) tied to immune response, particularly involving T cells.
- * Results suggest that genetic factors in NT1 also relate to other autoimmune diseases, indicating a shared immune mechanism influenced by environmental factors like infections and vaccinations.
Article Synopsis
- - Kleine-Levin syndrome (KLS) is a rare disorder causing severe episodes of sleepiness, cognitive issues, and changes in behavior, with unclear causes linked to brain activity and difficult births.
- - A global study identified a significant genetic association (rs71947865) related to KLS, particularly prevalent in patients with difficult birth histories and previously connected to bipolar disorder and schizophrenia.
- - Despite variations in findings across different sample sizes, the research highlights potential genetic and environmental factors, specifically involving circadian rhythms, that may contribute to the risk of developing KLS.
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted.
View Article and Find Full Text PDFBeyond a Binary Classification of Sex: An Examination of Brain Sex Differentiation, Psychopathology, and Genotype.
J Am Acad Child Adolesc Psychiatry
August 2019
Objective: Sex differences in the brain are traditionally treated as binary. We present new evidence that a continuous measure of sex differentiation of the brain can explain sex differences in psychopathology. The degree of sex-differentiated brain features (ie, features that are more common in one sex) may predispose individuals toward sex-biased psychopathology and may also be influenced by the genome.
View Article and Find Full Text PDFAnti-Yo paraneoplastic cerebellar degeneration (PCD) is a devastating autoimmune complication of gynecological cancers. We hypothesized that as for other autoimmune diseases, specific HLA haplotypes are associated. We conducted high resolution HLA typing of Class I/Class II in 40 cases versus ethnically matched controls.
View Article and Find Full Text PDFImportance: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation.
Objective: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases.
Data Sources: Genomewide association studies (GWAS) published up to January 15, 2015.