Publications by authors named "Ryan Goodman"
Background: In the USA, many states, including Colorado, have increased criminal penalties for illicit opioid possession, which may alter overdose risk. We aimed to evaluate the relationship between Colorado's increased drug-related criminal legal penalties, risk of overdose, and substance use patterns.
Methods: We used concept mapping - a mixed-methods approach used to develop a conceptual understanding of an issue from a community lens - to engage with people with living and/or lived experience with the criminal legal system, substance use, and/or overdose, their loved ones, and service providers.
Article Synopsis
- Impaired glucose metabolism in the brain is a key feature of Alzheimer's disease, with recent studies showing that glial cell metabolism is disrupted.
- Inhibition of the enzyme IDO1, which converts tryptophan into kynurenine, can improve memory function in mouse models of Alzheimer's by restoring how astrocytes (a type of brain cell) metabolize.
- IDO1 inhibition not only enhances glucose metabolism in the brain but also boosts the production of lactate, which is beneficial for neurons, suggesting potential for IDO1 inhibitors, originally designed for cancer, to be used in Alzheimer's treatment.
Article Synopsis
- Impaired glucose metabolism in the brain is a key feature of Alzheimer's disease (AD), affecting the function of astrocytes, which support neurons.
- Inhibiting the enzyme IDO1 restores memory and neuronal function in preclinical models by enhancing astrocytic glucose metabolism and lactate production.
- Targeting IDO1 could offer new therapeutic strategies for AD, as its inhibition improves neuronal health by supporting glucose metabolism in the presence of amyloid and tau pathology.
Article Synopsis
- Schizophrenia (SZ) is a severe mental illness characterized by symptoms like hallucinations, delusions, and cognitive difficulties, believed to be linked to neurotransmitter dysregulation.
- Researchers created induced neurons (iNs) from both SZ patients and healthy subjects to study neuropeptides, which are crucial for brain function, using advanced mass spectrometry techniques.
- The study found differences in neuropeptide secretion, particularly chromogranin B (CHGB), with SZ iNs showing lower levels and unique peptides compared to controls, indicating a potential model for understanding SZ-related neurotransmitter changes.
In the past 20 years, enzymatic conversions have been intensely examined as a practical and environmentally friendly alternative to traditional organocatalytic conversions for chemicals and pharmaceutical intermediate production. Out of all commercial enzymes, more than one-fourth are oxidoreductases that operate in tandem with coenzymes, typically nicotinamide adenine dinucleotide (NADH) or nicotinamide adenine dinucleotide phosphate (NADPH). Enzymes utilize coenzymes as a source for electrons, protons, or holes.
View Article and Find Full Text PDFA new approach of enhancing the adsorption capability of the widely used polymer adsorbent Tenax TA poly(2,6-diphenylene oxide) through its deposition on a nano-structured template is reported. The modified Tenax TA-coated silica nanoparticles (SNP) are incorporated as an adsorbent bed in silicon based micro-thermal preconcentrator (μTPC) chips with an array of square microposts embedded inside the cavity and sealed with a Pyrex cover. The interior surface of the chip is first modified by depositing SNP using a layer-by-layer self-assembly technique followed by coating with Tenax TA.
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