Publications by authors named "Ryan F Donelly"
Application of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan.
Cindy Kristina Enggi Sulistiawati Sulistiawati Achmad Himawan Muhammad Raihan Israini Wiyulanda Iskandar Ryan F Donelly
ACS Biomater Sci Eng
March 2024
Article Synopsis
- * The study developed a novel hydrogel-forming microneedle system combined with a tablet-like reservoir (HFMN-DCT) to enhance the transdermal delivery of TEL, utilizing materials like PVP, PVA, and tartaric acid.
- * Results showed that the new system improved the solubility and release of TEL significantly, demonstrated good mechanical properties, did not cause skin irritation, and performed well in both lab studies and tests on rats, indicating its potential for effective transdermal drug delivery.