Publications by authors named "Ryan Dingli Jiao"
Adv Sci (Weinh)
October 2024
Article Synopsis
- - Oligodendrocyte precursor cells (OPCs) rely on blood vessels for migration during central nervous system development, but the mechanisms that regulate their growth and transformation into oligodendrocytes are not yet fully understood.
- - The study found that removing the endothelial stimulator of interferon genes (STING) hampers blood vessel formation by affecting cholesterol synthesis, which negatively influences OPC development and myelination.
- - Disrupted metabolic balance in endothelial cells leads to increased interleukin 17D levels, which sends inhibitory signals to OPCs, resulting in abnormal behavior in adult mice, highlighting the importance of endothelial STING in OPC development in the neocortex.
