Publications by authors named "Ryan D Morris"
Front Cell Dev Biol
March 2022
Article Synopsis
- PIP5K1α is identified as a potential drug target for castration-resistant prostate cancer (CRPC) because it influences cancer growth and survival through the PI3K/AKT signaling pathway.
- Using siRNA and the small molecule inhibitor ISA-2011B, researchers found that reducing PIP5K1α levels leads to decreased growth and invasion of CRPC cells.
- The N-terminal domain of PIP5K1α is crucial for its function and stability, impacting the activity of the androgen receptor and related genes, indicating that targeting this kinase could be effective for CRPC treatment.
