Publications by authors named "Ryan Cragle"
Clin Cancer Res
August 2005
Article Synopsis
- Telomeres are crucial for protecting chromosome ends, and their dysfunction can lead to genome instability and cancer, with many tumors maintaining telomeres through telomerase or a process called ALT.
- In a study of liposarcoma samples, researchers found that 24% of tumors were ALT-positive, 27% utilized telomerase, while 49% showed neither mechanism for telomere maintenance.
- The findings indicate that about half of liposarcomas may have a new telomere maintenance method or lack one altogether, and recurrent tumors tend to have shorter telomeres regardless of maintenance strategies.
