Publications by authors named "Ryan Condon"
Histone deacetylase inhibitor decreases hyperalgesia in a mouse model of alcohol withdrawal-induced hyperalgesia.
Alcohol Clin Exp Res (Hoboken)
March 2024
Article Synopsis
- Alcohol withdrawal-induced hyperalgesia (AWH) results in heightened pain sensitivity after stopping chronic alcohol use, which can worsen withdrawal symptoms and increase relapse risk.
- * In this study, researchers assessed pain sensitivity in mice undergoing alcohol withdrawal through two different models: chronic drinking in the dark (DID) and the Lieber-DeCarli liquid diet.
- * Administering a histone deacetylase inhibitor (SAHA) during ethanol withdrawal improved pain sensitivity in mice on the Lieber-DeCarli diet, indicating a potential treatment for AWH.