Publications by authors named "Ryan Chaffee"
Pathogenic gram-negative bacteria frequently carry genes encoding extended-spectrum beta-lactamases (ESBL) and/or carbapenemases. Of great concern are carbapenem resistant , , and . Despite the need for rapid AMR diagnostics globally, current molecular detection methods often require expensive equipment and trained personnel.
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- Researchers created a new mouse model called EvoCaP to study how prostate cancer spreads to other parts of the body, including bones, liver, and lungs.
- They tracked tumor migration using a barcoding technique, finding that only a few aggressive clones are responsible for most of the cancer's spread, while the majority of cells stay localized.
- The study suggests that prostate cancer acts as a systemic disease driven by these aggressive clones, and understanding these patterns is crucial for developing new treatments.
Unlabelled: The dissemination of multidrug-resistant (MDR) STc131 is related to its persistence in the human gastrointestinal tract as efficient gut colonizers. Infection and prevention measures are the cornerstones for preventing STc131 spread. Oral decolonization therapies that target ST131 are being developed.
View Article and Find Full Text PDFHuntington's disease (HD) is a progressive neurological disorder whose non-motor symptoms include sleep disturbances. Whether sleep and activity abnormalities are primary molecular disruptions of mutant Huntingtin (mutHtt) expression or result from neurodegeneration is unclear. Here, we report Drosophila models of HD exhibit sleep and activity disruptions very early in adulthood, as soon as sleep patterns have developed.
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