Publications by authors named "Ryan C Splittgerber"
Article Synopsis
- Oncogene-induced senescence can help prevent tumor growth, but senescent cells can also produce factors that promote tumor development, making its therapeutic value uncertain.
- In a mouse model of metastatic melanoma, targeting aurora kinases with specific drugs led to reduced cell proliferation and induced senescence in tumors.
- Notably, half of the tumors did not progress over a year after stopping treatment, suggesting that combining senescence induction with immune responses is key to controlling melanoma growth.
Purpose: The purpose of this preclinical study was to determine the effectiveness of RAF265, a multikinase inhibitor, for treatment of human metastatic melanoma and to characterize traits associated with drug response.
Experimental Design: Advanced metastatic melanoma tumors from 34 patients were orthotopically implanted to nude mice. Tumors that grew in mice (17 of 34) were evaluated for response to RAF265 (40 mg/kg, every day) over 30 days.