Publications by authors named "Ryan C Ruger"
Article Synopsis
- Homozygous deletion of the MTAP gene is common in glioblastoma (GBM) and leads to significant epigenetic changes, including hypomethylation of pathways linked to cancer stem cells.
- Loss of MTAP increases the formation of glioma stem-like cells (GSCs) that express higher levels of CD133 and are associated with a worse prognosis for GBM patients.
- Targeting purine synthesis may effectively reduce the prevalence of these CD133-positive cells in MTAP-deficient GBM, providing a potential therapeutic approach.
