Publications by authors named "Ryan Brunetti"
Background: Left bundle branch area pacing (LBBAP) may be associated with greater improvement in left ventricular ejection fraction and reduction in death or heart failure hospitalization compared with biventricular pacing (BVP) in patients requiring cardiac resynchronization therapy. We sought to compare the occurrence of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) and new-onset atrial fibrillation (AF) in patients undergoing BVP and LBBAP.
Methods: The I-CLAS study (International Collaborative LBBAP Study) included patients with left ventricular ejection fraction ≤35% who underwent BVP or LBBAP for cardiac resynchronization therapy between January 2018 and June 2022 at 15 centers.
Background: Cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) is a well established therapy in patients with reduced left ventricular ejection fraction (LVEF), heart failure, and wide QRS or expected frequent ventricular pacing. Left bundle branch area pacing (LBBAP) has recently been shown to be a safe alternative to BVP.
Objectives: The aim of this study was to compare the clinical outcomes between BVP and LBBAP among patients undergoing CRT.
Article Synopsis
- - Transesophageal echocardiography (TEE) is used to detect endocarditis in patients with cardiac devices, but lead-based echodensities (LBEs) often appear and may not indicate infection.
- - A study reviewed 231 patients with cardiac devices, finding that most LBEs were in those being assessed for reasons unrelated to infection, and identified certain factors that influenced LBE occurrence.
- - The use of systemic anticoagulants was linked to fewer LBEs, while longer lead dwell time increased the odds of observing LBEs, hinting at possible thrombin fibrin makeup of these structures.
New onset atrial fibrillation in the ICU: An unexplored future of anticoagulation.
Pacing Clin Electrophysiol
November 2021
New-onset atrial fibrillation incidence and associated outcomes in the medical intensive care unit.
Pacing Clin Electrophysiol
August 2021
Background: In patients with critical medical illness, data regarding new-onset atrial fibrillation (NOAF) is relatively sparse. This study examines the incidence, associated risk factors, and associated outcomes of NOAF in patients in the medical intensive care unit (MICU).
Methods: This single-center retrospective observational cohort study included 2234 patients with MICU stays in 2018.
• This case describes an evolving LAA perforation complicating an attempted LAA occlusion. • This case describes detection and management of the complication under TEE guidance. • This case highlights the importance of diligent intraoperative procedural imaging.
View Article and Find Full Text PDFSerum cotinine is a sensitive and specific marker of tobacco exposure, including second-hand smoke exposure. We sought to explore the association of tobacco exposure determined by serum cotinine with electrocardiographic silent myocardial infarction (SMI). A total of 7,006 participants (59.
View Article and Find Full Text PDFWe previously reported that PGRN directly bound to TNF receptors (TNFR) in vitro and in chondrocytes (Tang, et al., Science, 2011). Here we report that PGRN also associated with TNFR in splenocytes, and inhibited the binding of TNFα to immune cells.
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