Transcriptomic analysis reveals the immune response of human microglia to a soy protein and collagen hybrid bioscaffold.

Inflammatory reactions resulting from spinal cord injury cause significant secondary damage. Microglial cells activate CD4 T cells via major histocompatibility complex class II (MHCII) molecules. The activated T cells lead to neural tissue damage and demyelination at early stages of spinal cord injury.

A Protein Composite Neural Scaffold Modulates Astrocyte Migration and Transcriptome Profile.

Bioscaffold implantation is a promising approach to facilitate the repair and regeneration of wounded neural tissue after injury to the spinal cord or peripheral nerves. However, such bioscaffold grafts currently result in only limited functional recovery. The generation of a neural scaffold using a combination of collagen and glutenin is reported.

Bioscaffold-based study of glioblastoma cell behavior and drug delivery for tumor therapy.

Glioblastoma multiforme (GBM) is a severe form of brain cancer with an average five-year survival rate of 6.7%. Current treatment strategies include surgical resection of the tumor area and lining the lesion site with therapeutics, which offer only a moderate impact on increasing survival rates.