Publications by authors named "Ryan Bayusantika Ristandi"

Background Objectives: Following World Health Organization (WHO) plans for thirty-five malaria-endemic countries, Indonesia will eliminate malaria by 2030. As one of the Indonesian provinces, West Java targeted subnational malaria elimination in 2022. This article aims to describe malaria surveillance data and elimination programs, including weaknesses in sustaining the program.

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Background: Tuberculosis (TB) is one of the major global health issues due to its high mortality rate, especially in low- and middle-income countries. One of the key success points of the TB eradication program is early TB diagnosis, which requires rapid and accurate diagnostic testing. This study aimed to evaluate the performance of a newly developed RT-PCR kit (Indigen MTB/DR-TB RT-PCR) in a routine TB clinical setting.

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Article Synopsis
  • The study aimed to compare gene expression and bacterial coinfection profiles in asymptomatic and mildly symptomatic COVID-19 patients using RNA sequencing of nasal swabs.* -
  • Results showed that asymptomatic patients experienced changes in macroautophagy and cell cycle processes, while mildly symptomatic patients had modifications in RNA transport and upregulation of certain genes, though no link between the severity of disease and viral variants was established.* -
  • The findings suggest that issues in autophagy and RNA processing could affect disease progression, highlighting the importance of considering bacterial coinfections like Streptococcus pneumoniae in symptomatic patients.*
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West Java Health Laboratory (WJHL) is one of the many institutions in Indonesia that have sequenced SARS-CoV-2 genome. Although having submitted a large number of sequences since September 2020, however, these submitted data lack advanced analyses. Therefore, in this study, we analyze the variant distribution, hotspot mutation, and its impact on protein structure and function of SARS-CoV-2 from the collected samples from WJHL.

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