Publications by authors named "Ryan B Salisbury"
Article Synopsis
- The voltage-gated calcium channel (VGCC) is made up of an α1 subunit and three auxiliary subunits, with the β subunit being crucial for moving the α1 subunit to the cell membrane and is extensively studied in calcium signaling.
- VGCCs play a critical role in calcium ion movement within neurons, influencing processes like dendritic spine plasticity, with dysfunction in this signaling linked to neurodevelopmental disorders such as schizophrenia.
- Overexpressing the β4 subunit in a mouse model reduced the density of small dendritic spines, with notable sex differences in this effect, indicating that interactions with other VGCC subunits, like β1b in males, may help protect against this reduction.
Mammalian axonal development begins in embryonic stages and continues postnatally. After birth, axonal proteomic landscape changes rapidly, coordinated by transcription, protein turnover, and post-translational modifications. Comprehensive profiling of axonal proteomes across neurodevelopment is limited, with most studies lacking cell-type and neural circuit specificity, resulting in substantial information loss.
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