Influence of primary cancer site on clinical outcomes of anticoagulation for associated venous thromboembolism.

Introduction: The outcome of anticoagulation for cancer-associated venous thromboembolism (Ca-VTE) differs according to cancer location, but data are limited and inconsistent.

Materials And Methods: Patients with acute venous thromboembolism (VTE) enrolled between 03/01/2013 and 04/30/2021 were followed prospectively to assess VTE recurrence, major bleeding (MB), clinically relevant non-major bleeding (CRNMB), and death.

Results: There were 1702 (45.

Bleeding in Patients With Gastrointestinal Cancer Compared With Nongastrointestinal Cancer Treated With Apixaban, Rivaroxaban, or Enoxaparin for Acute Venous Thromboembolism.

Objective: To compare the bleeding risk in patients with gastrointestinal (GI) cancer with that in patients with non-GI cancer treated with anticoagulation for acute cancer-associated venous thromboembolism (Ca-VTE).

Patients And Methods: Consecutive patients with Ca-VTE seen at the Mayo Thrombophilia Clinic between March 1, 2013, and April 20, 2020, were observed prospectively to assess major bleeding and clinically relevant nonmajor bleeding (CRNMB).

Results: In the group of 1392 patients with Ca-VTE, 499 (35.

Validation of a clinical rotation evaluation for physician assistant students.

Background: We conducted a prospective validation study to develop a physician assistant (PA) clinical rotation evaluation (PACRE) instrument. The specific aims of this study were to 1) develop a tool to evaluate PA clinical rotations, and 2) explore associations between validated rotation evaluation scores and characteristics of the students and rotations.

Methods: The PACRE was administered to rotating PA students at our institution in 2016.

Changes in incidence and indications of tonsillectomy and adenotonsillectomy, 1970-2005.

Objective: To investigate 35-year epidemiological trends in tonsillectomy and adenotonsillectomy. STUDY DESIGN/SUBJECTS: Cross-sectional survey. Subjects included all patients from birth to age 29 years who had tonsillectomy or adenotonsillectomy from 1970 to 2005.

Catheter ablation for atrial fibrillation in patients with obesity.

Background: Obesity is a risk factor for atrial fibrillation and other cardiovascular conditions. Our objective was to determine whether catheter-based ablation effectively treated atrial fibrillation in obese patients.

Methods And Results: Five hundred twenty-three consecutive patients with symptomatic, medication-refractory atrial fibrillation underwent catheter ablation.

Age and gender trends in implantable cardioverter defibrillator utilization: a population based study.

Introduction: Implantable cardioverter-defibrillators improve mortality in selected high risk patients, yet population based data regarding utilization of these devices, particularly in the elderly, are limited.

Methods: To address this, we reviewed all ICD implantations performed in Olmsted County, MN, a geographically defined population, between December 1989 and December 2004.

Results: The study population comprised 179 patients (147 male, 82%, mean age 65 +/- 14 years).

The incidence of ischemic stroke in chronic heart failure: a meta-analysis.

Background: There is marked variability in the reported stroke rates among persons with heart failure (HF). We performed a meta-analysis to provide summary estimates of the stroke rate in HF and to explain heterogeneity in the existing literature. We will summarize the ischemic stroke rate at various time points during follow-up among adults with chronic heart failure.

Systolic and diastolic heart failure in the community.

Context: The heart failure (HF) syndrome is heterogeneous. While it can be defined by ejection fraction (EF) and diastolic function, data on the characteristics of HF in the community are scarce, as most studies are retrospective, hospital-based, and rely on clinically indicated tests. Further, diastolic function is seldom systematically assessed based on standardized techniques.

Ischemic stroke after heart failure: a community-based study.

Background: Although studies have examined the incidence of stroke in heart failure (HF), their findings are inconsistent and difficult to interpret because of heterogeneity in study design and population. Although HF remains a highly fatal disease, the excess mortality imparted from stroke is unknown.

Methods: A random sample of cases of HF from 1979 to 1999 was identified and validated according to Framingham criteria.

The impact of observer and patient factors on the occurrence of digit preference for zero in blood pressure measurement in a hypertension specialty clinic: evidence for the need of continued observation.

Background: Many investigators have reported unconscious over-reporting of the terminal digit zero but little literature exists on observer or patient-related factors that may predict the occurrence. This study analyzes the occurrence of zero preference in 52,827 blood pressure (BP) measurements in 8513 patients by 11 hypertension nurse specialists in the Hypertension Division at Mayo Clinic, Rochester, Minnesota.

Methods: Data from the electronic database of the Hypertension Division from April 1997 to September 2001 were analyzed for the occurrence of zero preference.

Ventricular arrhythmias after acute myocardial infarction: a 20-year community study.

Background: Although myocardial infarction (MI) severity is declining, the occurrence of ventricular arrhythmia (VA) after MI and its effect on outcome is unknown. This study was undertaken to examine the frequency and timing of VA and the effect of VA on mortality after MI.

Methods: Myocardial infarctions recorded between 1979 and 1998 were validated.

The incidence of stroke after myocardial infarction: a meta-analysis.

Purpose: While the risk of stroke after myocardial infarction (MI) is increased compared with the risk among those without MI, the magnitude of this risk remains unclear. Although numerous clinical trials have reported the incidence of stroke following MI, these are among selected populations. We reviewed cohort studies reporting the incidence of stroke after MI to better define the risk of ischemic stroke in an unselected population.

Heart failure and death after myocardial infarction in the community: the emerging role of mitral regurgitation.

Background: In case series, mitral regurgitation (MR) increased the risk of death after myocardial infarction (MI), yet the prevalence of MR, its incremental prognostic value over ejection fraction (EF), and its association with heart failure and death after MI in the community is not known.

Methods And Results: The prevalence of MR and its association with heart failure and death were examined among 1331 patients within a geographically defined MI incidence cohort between 1988 and 1998. Echocardiography was performed within 30 days after MI in 773 patients (58%), and MR was present in 50% of cases, mild in 38%, and moderate or severe in 12%.

Cardiac rehabilitation after myocardial infarction in the community.

Objectives: The aim of this study was to examine participation in cardiac rehabilitation after myocardial infarction (MI) by age and gender and the association of participation with survival.

Background: Lesser participation in cardiac rehabilitation has been reported for women and the elderly.

Methods: All incident MIs in Olmsted County were validated.

Prevalence and secular trends of excess body weight and impact on outcomes after myocardial infarction in the community.

Objectives: To determine the trends in the prevalence of overweight and obese individuals among patients with myocardial infarction (MI), and to assess the association between weight and outcomes after MI.

Design: Population-based cohort study.

Methods: MIs occurring in Olmsted County, MN, between 1979 and 1998 were validated using standardized criteria.

Long-term outcomes of out-of-hospital cardiac arrest after successful early defibrillation.

Background: Mortality after out-of-hospital cardiac arrest from ventricular fibrillation is high. Programs focusing on early defibrillation have improved the rate of survival to hospital discharge. We conducted a population-based analysis of the long-term outcome and quality of life of survivors.