Publications by authors named "Ryan A Chan"
Analysis of decreases in systemic arterial pressure and heart rate in response to the hydrogen sulfide donor sodium sulfide.
Am J Physiol Heart Circ Physiol
October 2017
The actions of hydrogen sulfide (HS) on the heart and vasculature have been extensively reported. However, the mechanisms underlying the effects of HS are unclear in the anesthetized rat. The objective of the present study was to investigate the effect of HS on the electrocardiogram and examine the relationship between HS-induced changes in heart rate (HR), mean arterial pressure (MAP), and respiratory function.
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- Pulmonary hypertension is a serious condition that can be fatal within a few years if untreated, but current medications can help manage the disease by targeting blood vessels in the lungs.
- The study investigates the effectiveness of nebivolol, a drug that blocks β1 receptors and enhances nitric oxide (NO) production, in treating pulmonary hypertension in rats induced by monocrotaline.
- Results indicate that nebivolol can reduce symptoms associated with pulmonary hypertension, such as right ventricular hypertrophy and vascular remodeling, while also revealing that β3 receptors play a role in lowering blood pressure independently of NO release.