[Synthesis and chemical transformations of N-hydroxy- and N-hydroxyalkylcycloimides of chlorin p6].

Two series of chlorin p6 13,15-cycloimides that differ in their substituents at the nitrogen atom of the additional six-membered ring were synthesized. The compounds of the first series have a hydroxyl, alkoxyl, or acyloxy group at the 13,15-cycloimide nitrogen and those of the second series, residues of aliphatic alcohols. The cycloimides synthesized are satisfactorily stable and display an intensive light absorption maximum at 710-718 nm.

[Photobiological properties of 13,15-N-(carboxymethyl)- and 13,15-N-(2-carboxyethyl)cycloimide derivatives of chlorin p6].

Lipophilic derivatives of chlorin p6, 13,15-N-(carboxymethyl)cycloimide methyl ester (CIC1) and 13,15-N-(2-carboxyethyl)cycloimide methyl ester (CIC2), were shown to absorb light in 710 nm region and to be efficient IR photosensitizers. They exhibit similar phototoxicities on the cells of A549 human lung adenocarcinoma, which are 40- and 100-fold higher than those of chlorin p6 and the clinically used Photogem, respectively, and are not toxic in the absence of light irradiation. The confocal spectral imaging technique allowed us to demonstrate that the high phototoxicity of CIC1 and CIC2 is due to their ability to readily penetrate to cells and to be bound to the cell membranes and lipid-containing structures in the monomeric photoactive form.

[Comparative study of the state of health and nutrition of young children from rural and urban areas of the Uzbek SSR].

The study of the physical development including caliperometric investigations was conducted in 2620 infants. The food ingredients and caloric content were studied in the daily ration of 267 infants with premorbid signs. Parameters of the physical development (growth, body mass, chest circumference size, and standards of fat content in per cent) in infants can be recommended as reference ones in the region studied.