Contrast-Enhanced Computed Tomography Radiomics Predicts Colony-Stimulating Factor 3 Expression and Clinical Prognosis in Ovarian Cancer.

Rationale And Objectives: To develop a radiomics model for non-invasive prediction of colony-stimulating factor 3 (CSF3) expression in ovarian cancer (OC) and evaluate its prognostic value.

Materials And Methods: We acquired clinical data, genetic information, and corresponding computed tomography (CT) scans of OC from The Cancer Genome Atlas and The Cancer Imaging Archive repositories. We assessed the prognostic significance of CSF3 and its association with clinical features through the utilization of Kaplan-Meier analysis, univariate and multivariate Cox regression analysis, along with subgroup analysis.

High Expression of TBC1 Domain Family Member 22A is Related to Poor Prognosis in Ovarian Serous Cystadenocarcinoma.

TBC1 domain family member 22A (TBC1D22A) possesses GTPase-activating protein (GAP) activity of Rab family proteins and has not been reported in ovarian serous cystadenocarcinoma (OSC). The research was designed to evaluate the expression and prognostic effect of TBC1D22A in OSC. TCGA, GTEx, GEO, HPA, and GDSC databases were adopted to explore the oncogenic mechanism of TBC1D22A in OSC, as well as the correlation between TBC1D22A and patient prognosis, IC50, stemness index, immune checkpoint, and immune infiltration.

Identification of antigenic epitopes of monoclonal antibodies against the VP2 protein of the 25 serotype of bluetongue virus.

Serious outbreaks of bluetongue, an arbovirus of domestic and wild ruminants caused by bluetongue virus serotypes (BTV), have occurred around the world. More than 27 distinct serotypes are recognized throughout the world. A new virus, BTV-25 (Toggenburg orbivirus [TOV]), was first detected in Switzerland, and has not yet been found in China.