Smiles-Rearrangement-Based One-Pot Synthesis of Diarylacetylenes from Benzylic Sulfones and Methyl Benzoates Mediated by LiN(SiMe)/KN(SiMe).

The one-pot synthesis of diphenylacetylene by the reaction of methyl benzoate with 1-(benzylsulfonyl)-3,5-di(trifluoromethyl)benzene was developed. The combination of LiN(SiMe) and KN(SiMe) is key to promoting the reaction. Simply combining methyl benzoate, 1-(benzylsulfonyl)-3,5-di(trifluoromethyl)benzene, LiN(SiMe), and KN(SiMe) can produce a variety of diaryl acetylenes (28 examples, 18-70% yields).

One-Pot Synthesis of Indolin-3-ones Mediated by LiN(SiMe)/CsF.

Indolin-3-ones are essential heterocycles with wide-ranging biological activities and medicinal values, and therefore, efficient approaches to their synthesis remain in demand. Herein, a novel and operationally simple method to generate indolin-3-ones is reported by using a tandem reaction of -methylbenzylamines and methyl 2-fluorobenzoates mediated by the LiN(SiMe) and CsF system (34 examples, 30-85% yields). The synthesis of C2-quaternary indolin-3-one further demonstrated the potential practicability of these tandem reactions.

Metasurface-assisted amorphous germanium-tin waveguide bolometer for mid-infrared photodetection.

An amorphous germanium-tin (a-GeSn) waveguide bolometer featuring a one-dimension (1D) metasurface absorber is proposed for mid-infrared photodetection at room-temperature. The device is based on the germanium-on-silicon (GOS) photonic platform. The impacts of the 1D metasurface on the performances of the waveguide bolometer are investigated.

A Tandem Madelung Indole Synthesis Mediated by a LiN(SiMe)/CsF System.

A tandem Madelung indole synthesis by the reaction of methyl benzoate and -methyl--toluidine has been discovered. The combination of LiN(SiMe) with CsF is the key factor, which secures the high efficiency of such tandem transformations. Simply combining methyl benzoate, -methyl--toluidine LiN(SiMe), and CsF generated a diverse array of -methyl-2-phenylindoles (31 examples, 50-90% yields).

Dynamics and Functional Interplay of Nonhistone Lysine Crotonylome and Ubiquitylome in Vascular Smooth Muscle Cell Phenotypic Remodeling.

Background: The crotonylation of histones is discovered of late as one of the post-translational modifications (PTMs) that can regulate gene expression. However, the function of crotonylation on nonhistone proteins in vascular smooth muscle cells (VSMCs) is unclear. Here, we aim to find the cellular characteristics of crotonylated nonhistone proteins and the cross talk with ubiquitinated proteins in VSMC phenotypic remodeling using the modified omics and proteomic analysis.

Construction and Characterization of TiN/SiN Composite Insulation Layer in TiN/SiN/NiCr Thin Film Cutting Force Sensor.

The measurement of cutting force is an effective method for machining condition monitoring in intelligent manufacturing. Titanium nitride films and silicon nitride films were prepared on 304 stainless steel substrates by DC-reactive magnetron sputtering and plasma-enhanced chemical vapor deposition (PECVD). The effects of substrate negative bias and nitrogen flow on the surface microstructures of TiN film were investigated.