Evolutionary and functional analysis of metabotropic glutamate receptors in lampreys.

The metabotropic glutamate receptor (mGluR, GRM) family is involved in multiple signaling pathways and regulates neurotransmitter release. However, the evolutionary history, distribution, and function of the mGluRs family in lampreys have not been determined. Therefore, we identified the mGluRs gene family in the genome of Lethenteron reissneri, which has been conserved throughout vertebrate evolution.

Exploring the Multiple Roles of Notch1 in Biological Development: An Analysis and Study Based on Phylogenetics and Transcriptomics.

At present, there is a research gap concerning the specific functions and mechanisms of the gene family and its signaling pathway in jawless vertebrates. In this study, we identified a Notch1 homologue ( Notch1) in the database. Through bioinformatics analysis, we identified Notch1 as the likely common ancestor gene of the gene family in higher vertebrates, indicating a high degree of conservation in the gene family and its signaling pathways.