Publications by authors named "Ruyu Ren"

T cells are key drivers of the pathogenesis of autoimmune diseases by producing cytokines, stimulating the generation of autoantibodies, and mediating tissue and cell damage. Distinct mitochondrial metabolic pathways govern the direction of T-cell differentiation and function and rely on specific nutrients and metabolic enzymes. Metabolic substrate uptake and mitochondrial metabolism form the foundational elements for T-cell activation, proliferation, differentiation, and effector function, contributing to the dynamic interplay between immunological signals and mitochondrial metabolism in coordinating adaptive immunity.

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Stillbirth is a major global issue, with over 5 million cases each year. The multifactorial nature of stillbirth makes it difficult to predict. Artificial intelligence (AI) and machine learning (ML) have the potential to enhance clinical decision-making and enable precise assessments.

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Article Synopsis
  • * This study focused on the connection between SNPs in the IL23R and IL17A genes and the risk of developing RA in the Western Chinese Han population, examining genetic data from 246 RA patients and 362 healthy individuals.
  • * Results showed that specific SNPs (rs6693831 and rs1884444 in the IL23R gene) are significantly associated with RA susceptibility, with certain genotypes indicating a higher risk for developing the disease.
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Objective: To explore the association of single nucleotide polymorphisms (SNPs) in the transforming growth interacting factor (TGIF) gene with bone metabolism markers and rheumatoid arthritis (RA) susceptibility.

Methods: Three SNPs were genotyped in 155 RA patients and 168 healthy controls using high-resolution melting (HRM) analysis. The serum levels of osteocalcin, bone alkaline phosphatase (BALP), and β type I collagen-crosslinked C telopeptide (β-CTX) were detected using electrochemical luminescence in 108 patients randomly selected from the RA group.

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Background: Although PIWI-interacting RNAs (piRNAs) have recently been associated with germline development and many human diseases, their expression pattern and relationship in autoimmune diseases remain indistinct. This study aimed to investigate the presence and correlation of piRNAs in rheumatoid arthritis (RA).

Methods: We first analyzed the expression profile of piRNAs using small RNA sequencing in peripheral leukocytes of three new-onset untreated RA patients and three healthy controls (HCs).

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Portal hypertension is a common manifestation in late-to-end-stage liver diseases and can cause severe complications such as ascites, hepatic encephalopathy, etc. However, an early diagnosis of portal hypertension is often difficult as it can be asymptomatic. Though the gold standard to diagnose portal hypertension is hepatic vein catheterization, ultrasound elastography is regarded as a noninvasive alternative that can be used to accurately predict portal hypertension and a few further complications such as gastro-esophageal varices.

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Ankylosing spondylitis (AS) is a complex genetic disease characterized by axial skeletal inflammation. Available scientific evidence suggests that a relationship may exist between miRNA expression levels and the pathogenesis of AS. This study investigated the clinical diagnostic value of miR-146a, miR-15a, miR-20a, miR-125a-3p, miR-125a-5p, miR-125b-5p, miR-148a, miR-149a, miR-499, and miR-155a in AS.

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Synopsis of recent research by authors named "Ruyu Ren"

  • - Ruyu Ren's research primarily focuses on the genetic and metabolic factors influencing autoimmune diseases, particularly rheumatoid arthritis, as evidenced by studies examining gene polymorphisms and mitochondrial metabolism in T cells.
  • - The author is also exploring the application of machine learning techniques for enhancing clinical prediction and decision-making regarding stillbirth, highlighting the potential of AI in addressing complex health issues.
  • - Additionally, Ren has conducted studies on the role of microRNAs in inflammatory diseases, including their expression in ankylosing spondylitis, aiming to deepen the understanding of their contribution to disease pathogenesis and potential diagnostic applications.

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