Publications by authors named "Ruyin Guo"
Short airway telomeres are associated with primary graft dysfunction and chronic lung allograft dysfunction.
J Heart Lung Transplant
December 2023
Primary graft dysfunction (PGD) is a major risk factor for chronic lung allograft dysfunction (CLAD) following lung transplantation, but the mechanisms linking these pathologies are poorly understood. We hypothesized that the replicative stress induced by PGD would lead to erosion of telomeres, and that this telomere dysfunction could potentiate CLAD. In a longitudinal cohort of 72 lung transplant recipients with >6 years median follow-up time, we assessed tissue telomere length, PGD grade, and freedom from CLAD.
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- Cells can get used to cold temperatures by changing their fats and making their membranes more flexible.
- Scientists found a big protein called LPD-3 in tiny worms (C. elegans) that helps move fats around inside the cells to help them survive cold better.
- When LPD-3 doesn't work right, the worms can't handle the cold as well, and this problem is similar in other animals, including fish and humans.