Publications by authors named "Ruyi Liu"

Angiopoietin‑like 4 (ANGPTL4), a member of the angiopoietin family, plays critical roles in angiogenesis, lipid metabolism and inflammation. It has been demonstrated that ANGPTL4 has significant influence on various diseases. Accumulating evidence has highlighted the impacts of ANGPTL4 on human malignancies.

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Aim: to investigate hepatopancreatoduodenectomy (HPD) application in gallbladder carcinoma (GBC) and compare it to radical cholecystectomy (RC) regarding patients' characteristics, surgical outcome and survival.

Methods: Patients treated in our center were included. Three groups (HPD, RC, no-surgery) were compared.

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Introduction: Within the maintenance phase of visual working memory (VWM), previous researchers presented retro-cues orienting to a probed dimension across all multidimension stimuli and found a robust dimension-based retro-cue benefit (RCB): VWM performance for cued dimension was better than no/neutral-cue baseline. This improvement is often attributed to the prioritization of information related to the focused dimension and the removal of information related to the unfocused dimension from VWM. However, it remains unclear whether the removal of the uncued dimension is necessary to observe this dimension-based RCB.

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Capacity-limited visual working memory (VWM) requires that individuals have sufficient memory space and the ability to filter distractors. Negative emotional states are known to impact VWM storage, yet their influence on distractor filtering within VWM remains underexplored. We conducted direct neural measurement of participants (n = 56) who conducted a lateralized change detection task with distractors, while manipulating the emotional state by presenting neutral or negative images before each trial.

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Article Synopsis
  • Flavonoids make tea taste bitter and help tea plants deal with stress from things like sunlight and heat.
  • A protein called CsMYB67 is important for making flavonoids in tea leaves and responds to temperature changes.
  • When CsMYB67 works with another protein, CsTTG1, it helps increase the production of special pigments called anthocyanins, which are part of flavonoids in tea.
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Microplastics (MPs) have attracted much attention in recent years, due to the difficulty of degradation and threats to ecological systems and humans. Based on the analysis of 1429 articles on MPs in soil, we found that we know little about the behavior and fate of manure-born MPs from the livestock and poultry production systems to agriculture soils. This review summarizes the analytical methods for sampling, separation, and identification and the occurrence of MPs in livestock and poultry manure, mainly based on 7 surveys related to manure-born MPs.

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The key components dominating the quality of green tea and black tea are still unclear. Here, we respectively produced green and black teas in March and June, and investigated the correlations between sensory quality and chemical compositions of dry teas by multivariate statistics, bioinformatics and artificial intelligence algorithm. The key chemical indices were screened out to establish tea sensory quality-prediction models based on the result of OPLS-DA and random forest, namely 4 flavonol glycosides of green tea and 8 indices of black tea (4 pigments, epigallocatechin, kaempferol-3-O-rhamnosyl-glucoside, ratios of caffeine/total catechins and epi/non-epi catechins).

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The two-stage preference design (TSPD) enables inference for treatment efficacy while allowing for incorporation of patient preference to treatment. It can provide unbiased estimates for selection and preference effects, where a selection effect occurs when patients who prefer one treatment respond differently than those who prefer another, and a preference effect is the difference in response caused by an interaction between the patient's preference and the actual treatment they receive. One potential barrier to adopting TSPD in practice, however, is the relatively large sample size required to estimate selection and preference effects with sufficient power.

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Sperm with normal morphology and motility are essential for successful fertilization, and the strong attachment of the sperm head-tail coupling apparatus to the nuclear envelope during spermatogenesis is required to ensure the integrity of sperm for capacitation and fertilization. Here, we report that Arrdc5 is associated with spermatogenesis. The Arrdc5 knockout mouse model showed male infertility characterized by a high bent-head rate and reduced motility in sperm, which led to capacitation defects and subsequent fertilization failure.

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Currently, purely organic compounds showing ambient phosphorescence with high efficiency (Φ ) and ultra-long lifetime (τ ) are quite rare and often need to be achieved in hydrophilic poly(vinyl alcohol)-based hosts. This severely limits their applications. Here, we provide a solution to this issue by constructing an ortho-linked donor-acceptor (D-A) dyad whose D moiety has not only a long-lived T state to achieve a long τ , but also a T state that is close to the S state of the dyad to trigger effective spin-orbit charge transfer intersystem crossing (SOCT-ISC).

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Oocyte maturation defects are major phenotypes resulting in female infertility. Although many genetic factors have been found to be responsible for these phenotypes, the underlying pathogenic genes and variants remain to be identified. The anaphase promoting complex or cyclosome (APC/C) is known to be essential in the metaphase-to-anaphase transition.

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Layered indium selenide (InSe) is a new 2D semiconductor material with high carrier mobility, widely adjustable bandgap, and high ductility. However, its ion storage behavior and related electrochemical reaction mechanism are rarely reported. In this study, InSe nanoflakes encapsulated in conductive polypyrrole (InSe@PPy) are designed in consideration of restraining the severe volume change in the electrochemical reaction and increasing conductivity via in situ chemical oxidation polymerization.

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Article Synopsis
  • * Mutations in PATL2 have been linked to issues in oocyte maturation and embryonic development, but its exact role was not well understood until this study.
  • * This research shows that PATL2 interacts with other proteins to control maternal mRNA and reveals that its phosphorylation affects protein levels, impacting fertility in mice with specific mutations.
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Normal oocyte maturation is an important requirement for the success of human reproduction, and defects in this process will lead to female infertility and repeated IVF/ICSI failures. In order to identify genetic factors that are responsible for oocyte maturation defect, we used whole exome sequencing in the affected individual with oocyte maturation defect from a consanguineous family and identified a homozygous variant c.853_861del (p.

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γCbPhAP, a D-A dyad with γ-carboline as the D unit and 3-phenylacenaphtho[1,2-]pyrazine-8,9-dicarbonitrile as the A moiety and phosphorescence core, was designed and synthesized. The doping system of 1 wt% γCbPhAP in PMMA shows red ambient phosphorescence-dominated afterglow with long lifetime of 0.5 s and decent efficiency over 12%.

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In visual working memory (VWM) tasks, participants' performances can be improved through the use of dimension-based retro-cues, which direct internal attention to prioritize a particular dimension (e.g., color or orientation) of VWM representations even after the stimuli disappear.

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Fertilization is a fundamental process of development, and the blocking mechanisms act at the zona pellucida (ZP) and plasma membrane of the egg to prevent any additional sperm from binding, permeating and fusing after fertilization. In clinical practice, some couples undergoing recurrent IVF failures that mature oocytes had abnormal fertilization for unknown reason. Ovastacin encoded by ASTL cleave the ZP protein ZP2 and play a key role in preventing polyspermy.

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Article Synopsis
  • Matcha is a special green tea powder that has a unique flavor and color, and it can be used in lots of foods like drinks, snacks, and dairy products.
  • The way matcha is grown and processed makes a big difference in its taste and health benefits, with shading the tea plants being an important step to make it greener and tastier.
  • The review talks about the good stuff in matcha, like its healthy ingredients and how they are good for our stomachs, particularly how they can help the tiny bacteria in our guts.
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Asthenozoospermia is one of the main factors leading to male infertility, but the genetic mechanisms have not been fully elucidated. Variants in the androglobin (ADGB) gene were identified in an infertile male characterized by asthenozoospermia. The variants disrupted the binding of ADGB to calmodulin.

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Temperature and humidity play an important role in plant-pathogen interactions. However, regulating the temperature and humidity specifically to inhibit the development of plant diseases remains unclear. In this study, we explored the influence of intermittent temperature and humidity variation on tomato gray mold.

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  • Ovarian dysfunction, like premature ovarian insufficiency, is a major cause of female infertility, increasingly linked to genetic factors.* -
  • This study identified eight genetic variants in five specific genes through exome sequencing from six different families, noting that some variants affect protein production.* -
  • The research expands knowledge of ovarian dysfunction's genetic aspects and suggests potential biomarkers for personalized treatments, with exome sequencing providing a genetic diagnosis in about 5% of ovarian dysfunction cases.*
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  • Scientists found a new gene called IQUB that causes male infertility, especially when sperm can't swim well (a condition called asthenospermia).
  • The research was done by looking at 126 men with infertility problems over several years and using special mouse models to study the gene's effects.
  • The findings showed that a specific change in the IQUB gene linked to infertility was identified and confirmed in the mice, which helps understand the causes of this condition better.
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Purpose: The genetic causes of oocyte maturation arrest leading to female infertility are largely unknown, and no population-based genetic analysis has been applied in cohorts of patients with infertility. We aimed to identify novel pathogenic genes causing oocyte maturation arrest by using a gene-based burden test.

Methods: Through comparison of exome sequencing data from 716 females with infertility characterized by oocyte maturation arrest and 3539 controls, we performed a gene-based burden test and identified a novel pathogenic gene LHX8.

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