Publications by authors named "Ruxin Jin"
Article Synopsis
- Collective cell migration (CCM) is crucial for various biological processes like embryonic development, blood vessel formation, and tumor progression, but the specific mechanisms, especially regarding how leader cells are formed, are not well understood.
- This study identifies a signaling pathway that regulates the cleavage of angiomotin (AMOT), showing that when AMOT is cleaved, it promotes leader cell formation and enhances the motility of cells within a group.
- The cleavage of AMOT switches the cells from being tightly connected (which restricts movement) to a more fluid state that facilitates collective and coordinated migration, highlighting its role as a regulator in CCM.
Diffuse pleural mesothelioma (DPM) is a lethal cancer with a poor prognosis and limited treatment options. The Hippo signaling pathway genes, such as NF2 and LATS1/2, are frequently mutated in DPM, indicating a tumor suppressor role in the development of DPM. Here, we show that in DPM cell lines lacking NF2 and in mice with a conditional Nf2 knockout, downregulation of WWC proteins, another family of Hippo pathway regulators, accelerates DPM progression.
View Article and Find Full Text PDFThe Hippo pathway is a central regulator of organ size and tumorigenesis and is commonly depicted as a kinase cascade, with an increasing number of regulatory and adaptor proteins linked to its regulation over recent years. Here, we propose that two Hippo signaling modules, MST1/2-SAV1-WWC1-3 (HPO1) and MAP4K1-7-NF2 (HPO2), together regulate the activity of LATS1/2 kinases and YAP/TAZ transcriptional co-activators. In mouse livers, the genetic inactivation of either HPO1 or HPO2 module results in partial activation of YAP/TAZ, bile duct hyperplasia, and hepatocellular carcinoma (HCC).
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