Publications by authors named "Ruxandra Laza"

The emergence of SARS-CoV2 has presented itself as a significant global health crisis. The prevalence of thrombotic events is known to be high in these patients, affecting various organ systems, sometimes leading to cutaneous thrombosis, pulmonary embolism (PE), stroke, or coronary thrombosis. The available evidence suggests that thromboembolism, hypercoagulability, and the excessive production of proinflammatory cytokines play a significant role in the development of multiorgan failure.

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Purpose: The COVID-19 pandemic has determined an extraordinary challenge to healthcare systems worldwide. The extraordinary circumstances, characterized by elevated stress levels, prolonged working hours, new medical procedures, media attention, and high population expectations, have created an extremely stressful situation for healthcare professionals. This period has offered a unique opportunity to examine the medical system and the responses of healthcare practitioners to stress.

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Article Synopsis
  • - This study systematically reviewed the use of point-of-care ultrasound (POCUS) for diagnosing and managing posterior cruciate ligament (PCL) injuries, hypothesizing it could match the diagnostic accuracy of MRI while offering better patient outcomes and lower costs.
  • - Seven studies involving 242 patients were analyzed, showing POCUS sensitivity between 83.3% to 100% and specificity between 86.7% to 100%, with some studies reporting 100% accuracy in diagnosing PCL injuries.
  • - The results indicate that POCUS is a reliable and cost-effective alternative to MRI for PCL injuries, which could enhance patient care and inform future clinical practices and research.
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Data on bacterial or fungal pathogens and their impact on the mortality rates of Western Romanian COVID-19 patients are scarce. As a result, the purpose of this research was to determine the prevalence of bacterial and fungal co- and superinfections in Western Romanian adults with COVID-19, hospitalized in in-ward settings during the second half of the pandemic, and its distribution according to sociodemographic and clinical conditions. The unicentric retrospective observational study was conducted on 407 eligible patients.

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The Roma population accounts for over 3% (approximately 10 to 15 million) of Romania's permanent population, and it represents one of Europe's most impoverished populations. Due to poverty and unemployment, Romania's Roma minority may have diminished access to healthcare and preventive medicine. The limited existing evidence suggests that the European Roma group has been at a higher risk of becoming ill and dying during the pandemic owing to their lifestyle choices, socioeconomic circumstances, and genetic pathophysiological traits.

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Article Synopsis
  • Research indicates that severe COVID-19 is associated with increased levels of inflammatory markers, and certain demographic factors, like race and ethnicity, influence infection severity.
  • The Roma community is shown to be at higher risk for severe COVID-19 due to socio-economic factors, as demonstrated in a study comparing 83 Roma patients to 236 Romanian patients with severe illness.
  • Findings revealed that Roma patients had higher rates of obesity, hypertension, and diabetes, along with longer hospital stays and elevated inflammatory markers upon admission.
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Background and objectives: The postpartum maternal physical and psychological state played a fundamental role in the mother−child relationship at the beginning of the COVID-19 pandemic. The aim of the study is to analyze the influence of maternal psychological manifestations on the mother−child couple through three objectives (briefly expressed): (I) Determination of the main acute and chronic conditions of newborns/infants. (II) Verification of the hypothesis of the existence of a link between the following neonatal variables: gestational age, birth weight, number of days of hospitalization, and specific neonatal therapies (oxygen, surfactant, and blood products’ transfusion).

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Purpose: The purpose of this study is to identify the relationships between postpartum emotional manifestations and various neonatal variables, as well as variables within this category, in the context of hospitalization together after birth.

Patients And Methods: Between 1 March 2020 and 1 September 2020, a cross-sectional research design was used including mother-child couples (112 mothers, 121 newborns - 13 twins/triplets).

Results: Using a -test for independent samples, we observed: a) the symptoms of depression were more severe in mothers of newborns hospitalized in neonatal intensive care units (NICUs) [(110) = 4.

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Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to cause a diverse spectrum of clinical manifestations ranging from mild, flu-like symptoms to severe progressive pneumonia, acute respiratory distress syndrome with or without other extrapulmonary impairment. Hematological changes such as lymphopenia, neutrophilia, and anemia as the disease progresses, are frequently found in COVID-19. Thrombocytopenia may be drug-induced or can occur secondary to sepsis, disseminated intravascular coagulation or bone marrow suppression.

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Purpose: Romania is one of the European countries that has been hit the hardest by the severe acute respiratory syndrome caused by the new coronavirus SARS-CoV-2, with over 1.91 million reported cases and over 59,257 deaths. The aim of this study was to identify the main predictors of death in hospitalized patients.

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During the last decade, several changes in the epidemiology, clinical symptoms, and evolution of infection (CDI) have been reported. The number of diagnosed cases has increased, especially in individuals over 60 years of age. There has also been an increase in the share of severe forms of the disease, the number of patients with recurrent infections and the lethality caused by this condition.

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Article Synopsis
  • - The study investigates the incidence and risk factors for Clostridium difficile infection (CDI) in COVID-19 patients, finding 40 cases among 2065 hospitalized patients, mostly associated with hospital settings.
  • - CDI significantly impacted the recovery and duration of hospital stays for COVID-19 patients, particularly in those with comorbidities or recent hospitalizations, with longer stays (36 days) compared to those without CDI (28 days).
  • - Clinicians need to be cautious about the risk of CDI in COVID-19 patients, especially due to the frequent use of antibiotics during the pandemic, which can lead to severe complications.
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Patients with severe COVID-19 experience high-stress levels and thus are at risk for developing acute stress disorder (ASD) and/or post-traumatic stress disorder (PTSD). The present study aims to search for correlations between psychiatric response to stress and coping strategies among individuals with acute vs. remitted COVID-19.

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Article Synopsis
  • SARS-CoV-2 emerged as a highly contagious virus in December 2019, leading to the COVID-19 pandemic declared by the WHO within three months, resulting in over 3 million deaths and various unexplained symptoms, such as skin rashes.
  • This study focused on observing skin manifestations in patients hospitalized during the second and third COVID-19 outbreaks in Timis, documenting clinical progress and lab results for five indicative cases.
  • The findings aim to enhance understanding of SARS-CoV-2 infection and its effects, contributing to global medical and scientific efforts to better respond to the pandemic and associated symptoms.
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Background: Acinetobacter baumannii is one of the main causes of morbidity and mortality in critical condition patients. The pathogen's ability to survive under a wide range of environment conditions and to persist for long periods of time on areas represents a frequent cause of endemic infection hotbeds especially in the Intensive Care Unit. The objectives of the study are: determining the 5-year incidence of A.

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Background: The recent emergence of Clostridium difficile infections has included this condition among top nosocomial infections, due to its incidence, complications and important fatality, as well as to significant economic costs.

Methods: A prospective surveillance study of Clostridium difficile enterocolitis cases was performed in "Victor Babeş" Infectious Diseases Hospital in Timişoara (Romania) between 01.01.

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Tuberculosis is a frequent cause of prolonged fever. Mediastinal lymph node enlargement is an uncommon feature of intrathoracic tuberculosis in adults. The authors present the case of a 64 year old man who developed prolonged fever and was admitted to Clinical Hospital of Infectious Diseases and Pneumophtisiology Dr.

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In our country prolonged fever is frequently caused by tuberculosis infection, that is recrudescent. Localized hepatic tuberculosis is a rare clinical form of this specific infection. The authors present the case of a 26 year old man who developed prolonged fever, highly elevated liver enzymes and meningitis syndrome and was admitted to Clinical Hospital of Infectious Diseases and Pneumophtisiology Dr.

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Pulmonary alveolar proteinosis can be associated with various microorganisms and Pneumocystis jirovecii is one of them, especially in AIDS patients. Authors present the case of a 30-year-old man treated with corticosteroids for idiopathic pulmonary fibrosis, having restrictive ventilatory disfunction and bilateral perihilar interstitial infiltrates, ground-glass opacity on CT of the lungs. Rapid extension ofpulmonary a bnormalities (over a month) to peripheral reticular lesions and presence of fever were considered as Hamman-Rich syndrome.

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Since the earliest days of systematic thermometry prolonged fever illness has fascinated and generated many frustrations to clinicians and laboratory physicians. The authors present peculiarities of 57 patients with prolonged fever illness that were admitted to 2nd Clinic of Infectious Diseases from "Dr.V.

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