Publications by authors named "Ruut Piri"
Article Synopsis
- Differentiating between viral and bacterial infections in febrile children is crucial for preventing unnecessary antibiotic use, and MxA is identified as a potential biomarker for this purpose.
- A study with 228 febrile children compared a point-of-care (POC) MxA blood measurement to a reference method, finding that the POC results were consistent in 87.3% of cases.
- The POC MxA measurement effectively distinguished between viral and bacterial infections, achieving 92% sensitivity and 91% specificity at a cutoff of 101 µg/L.
A biomarker for viral infection could improve the differentiation between viral and bacterial infections and reduce antibiotic overuse. We examined blood myxovirus resistance protein A (MxA) as a biomarker for viral infections in children with an acute infection. We recruited 251 children presenting with a clinical suspicion of serious bacterial infection, determined by need for a blood bacterial culture collection, and 14 children with suspected viral infection at two pediatric emergency departments.
View Article and Find Full Text PDFPrevalence of respiratory viruses and antiviral MxA responses in children with febrile urinary tract infection.
Eur J Clin Microbiol Infect Dis
July 2020
Blood myxovirus resistance protein A (MxA) has broad antiviral activity, and it is a potential biomarker for symptomatic virus infections. Limited data is available of MxA in coinciding viral and bacterial infections. We investigated blood MxA levels in children hospitalized with a febrile urinary tract infection (UTI) with or without simultaneous respiratory virus infection.
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