Publications by authors named "Ruut Piri"

Article Synopsis
  • Differentiating between viral and bacterial infections in febrile children is crucial for preventing unnecessary antibiotic use, and MxA is identified as a potential biomarker for this purpose.
  • A study with 228 febrile children compared a point-of-care (POC) MxA blood measurement to a reference method, finding that the POC results were consistent in 87.3% of cases.
  • The POC MxA measurement effectively distinguished between viral and bacterial infections, achieving 92% sensitivity and 91% specificity at a cutoff of 101 µg/L.
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A biomarker for viral infection could improve the differentiation between viral and bacterial infections and reduce antibiotic overuse. We examined blood myxovirus resistance protein A (MxA) as a biomarker for viral infections in children with an acute infection. We recruited 251 children presenting with a clinical suspicion of serious bacterial infection, determined by need for a blood bacterial culture collection, and 14 children with suspected viral infection at two pediatric emergency departments.

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Blood myxovirus resistance protein A (MxA) has broad antiviral activity, and it is a potential biomarker for symptomatic virus infections. Limited data is available of MxA in coinciding viral and bacterial infections. We investigated blood MxA levels in children hospitalized with a febrile urinary tract infection (UTI) with or without simultaneous respiratory virus infection.

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