New repertory, new considerations.

The criteria for entering medicines in repertory rubrics are unclear and partly incorrect. A new repertory should be based on clear and objective criteria. Retrospective and prospective assessment of medicines and symptoms by the Dutch Committee for Methods and Validation gives an indication of the validity of existing repertory entries.

Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women.

Aims: To determine whether peri-coronary epicardial adipose tissue (EAT) is associated with vascular risk factors and coronary atherosclerosis.

Methods And Results: In this study, 573 healthy post-menopausal women underwent a cardiac CT scan to assess coronary calcification. Peri-coronary EAT thickness was measured in the areas of right coronary artery (RCA), left anterior descending (LAD) artery, and left circumflex (LCX) coronary artery.

Clear-cell dermal duct tumour: another distinctive, previously underrecognized cutaneous adnexal neoplasm.

Aims: To describe 13 examples of clear cell dermal duct tumour, a neoplasm previously underrecognized in the literature.

Methods And Results: Thirteen examples of a neoplasm that we have named clear-cell dermal duct tumour were studied histopathologically and immunohistochemically. Histopathologically, all lesions consisted of mostly dermal neoplasms mainly composed of multiple solid aggregations of clear cells involving the dermis.

Fibrous papule of the face with granular cells.

Fibrous papule of the face is a common benign lesion located most often on the nose. It presents usually as a single small, firm, skin-coloured papule and is often misdiagnosed as melanocytic naevus, wart or small nodular basal cell carcinoma. Histopathologically, the lesions are characterized by involvement of the upper dermis by a fibrovascular proliferation and scattered triangular or stellate, often multinucleated cells.

Coronary calcification: effect of small variation of scan starting position on Agatston, volume, and mass scores.

Purpose: To retrospectively evaluate the effect of a small variation of scan starting position on coronary artery calcium scores based on nonoverlapping 3-mm multidetector computed tomographic (CT) data sets.

Materials And Methods: Informed consent and institutional review board approval were obtained. A retrospective study was performed by using prospective unenhanced electrocardiographically triggered cardiac multidetector CT scans in 228 women (mean age, 67 years +/- 5 [standard deviation]).

[Malignant melanoma in children and adolescents].

According to data from the literature and to new data from the German central registry for malignant melanomas from the German Society of Dermatology, a summary is given about the occurrence of malignant melanoma in children and adolescents up to 18 years of age. During the first 10 years of life the occurrence of a melanoma is extremely rare, but slowly increases after the first decade. Several studies have shown that young people often have amelanotic tumors resembling pyogenic granuloma.

[Spitz nevus vs 'spitzoid' malignant melanoma. A diagnostic dilemma?].

Data from the literature and histopathological findings in six personal cases are used to illustrate criteria that can be applied in differential diagnosis between a Spitz nevus and a spitzoid variant of malignant melanoma. The diagnostic term 'atypical Spitz tumor' is explained; it is used to describe a morphological "grey zone" in which it is not possible to differentiate with adequate certainty between a Spitz nevus and a spitzoid malignant melanoma.

[Sedentary lifestyles. Classification of different target groups for the promotion of health-enhancing physical activities].

The article investigates different sub-groups of sedentary adults based on their socio-demographic characteristics and perceived barriers to physical activity. Data stem from the Germans Survey of Sedentary Adults (n=10.000) and the data analysis used logistic regressions and cluster analysis.

Cutaneous sebaceous neoplasms with a focal glandular pattern (seboapocrine lesions): a clinicopathological study of three cases.

Presented here are three cutaneous sebaceous tumors (one carcinoma and two sebaceomas), each demonstrating a focal glandular pattern representing apocrine differentiation. The patients, two males and one female, each clinically presented with a small solitary nodule or tumor on the scalp. None of the patients had features of Muir-Torre syndrome.

Preventing falls in physically active community-dwelling older people: a comparison of two intervention techniques.

Background: Falls are common in physically active older people; however, most intervention studies have been targeted at frail older people.

Objective: To evaluate the effectiveness of two intervention techniques for preventing falls in physically active community-dwelling older people.

Methods: Two hundred and seventeen people (120 men and 97 women) aged between 70 and 90 years recruited from a health insurance company membership database were randomly allocated to receive either a psychomotor intervention focusing on body awareness, body experience and coordination, a fitness intervention focusing on functional skills, strength, endurance and flexibility, or no intervention (control group).

Tubular adenoma and syringocystadenoma papilliferum: a reappraisal of their relationship. An interobserver study of a series, by a panel of dermatopathologists.

Tubular adenoma (TA) and syringocystadenoma papilliferum (SCAP) may show histopathological overlap, with some lesions having features of both neoplasms (SCAP + TA). TA has been recently suggested to represent a carcinoma. Four observers blindly assessed 67 cases of TA, SCAP, and their lookalikes (poroma, apocrine adenoma, apocrine carcinoma; all lesions focally featuring a pseudopapillary pattern), and classified the lesions into one of four categories: (1) TA, (2) SCAP, (3) SCAP + TA, and (4) others.

Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma?

Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is a recently proposed entity and constitutes the cutaneous counterpart of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). The t(14;18)(q32;q21) involving the IGH and the MALT1 gene has previously been described in PCMZL, whereas the t(14;18)(q32;q21) IGH/BCL2 seems to be restricted to follicular lymphoma and diffuse large B-cell lymphoma. We screened 30 PCMZLs of 13 patients by fluorescent in situ hybridization analysis for the presence of the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21)IGH/MALT1.

Contrast agents in X-ray computed tomography and its applications in oncology.

Intravascular iodinated contrast agents are required for a large proportion of computed tomography (CT) studies. Contrast media are indispensable to more clearly differentiate anatomic structures and to detect and characterize abnormalities. Depending on the indication up to 200 ml of these agents are injected during CT.

Detection of coronary calcifications from computed tomography scans for automated risk assessment of coronary artery disease.

A fully automated method for coronary calcification detection from non-contrast-enhanced, ECG-gated multi-slice computed tomography (CT) data is presented. Candidates for coronary calcifications are extracted by thresholding and component labeling. These candidates include coronary calcifications, calcifications in the aorta and in the heart, and other high-density structures such as noise and bone.

Bayesian homeopathy: talking normal again.

Homeopathy has a communication problem: important homeopathic concepts are not understood by conventional colleagues. Homeopathic terminology seems to be comprehensible only after practical experience of homeopathy. The main problem lies in different handling of diagnosis.

The expanding spectrum of Galli-Galli disease.

Galli-Galli disease (GGD), a rare genodermatosis in the spectrum of reticulate hyperpigmentation, is regarded as an acantholytic variant of Dowling-Degos disease. We herein report two patients with GGD exhibiting erythematous scaly plaques and lentigo-like macules on the trunk and lower extremities, rather than the characteristic reticulate hyperpigmented macules of large body folds. Digitate elongations of rete ridges coupled with foci of acantholysis were the clues to the diagnosis.

Inter-scan reproducibility of coronary calcium measurement using Multi Detector-Row Computed Tomography (MDCT).

Purpose: To assess inter-scan reproducibility of coronary calcium measurements obtained from Multi Detector-Row CT (MDCT) images and to evaluate whether this reproducibility is affected by different measurement protocols, slice thickness, cardiovascular risk factors and/or technical variables.

Design: Cross-sectional study with repeated measurements.

Materials And Methods: The study population comprised 76 healthy women.

Vedaprofen therapy in cats with upper respiratory tract infection or following ovariohysterectomy.

Objectives: The antipyretic and analgesic efficacy of vedaprofen (at a dose of 0.5 mg/kg) was evaluated after repeated once-daily administration (for three or five days) to 80 cats with upper respiratory tract disease or 302 cats undergoing ovariohysterectomy.

Methods: Both clinical trials were randomised, double blinded and placebo controlled.

High blood pressure in pregnancy and coronary calcification.

A considerable proportion of pregnant women develop high blood pressure in pregnancy. Although it is assumed that this condition subsides after pregnancy, many of these women develop the metabolic syndrome later in life and are at increased risk to develop coronary heart disease. Atherosclerosis development is considered in between risk factors and occurrence of vascular symptoms.

[Physical activity and health. Evidence for the health benefits of different physical activity promotion concepts].

Recent years have been marked by increased efforts of public health to pro mote physical activity. Concepts used for the promotion of physical activity range from the prescription of exercise to advice for "active living". The article compares existing evidence for the health benefits of the concepts of physical activity, health-enhancing physical activity, exercise and the German concept of "health sport".

[Extrafacial granuloma eosinophilicum].

Three patients with a rare extrafacial granuloma eosinophilicum are presented. Lesions were localized on the scalp, the upper back or the upper arm. Only one patient had a typical facial granuloma eosinophilicum at the same time.

Pilot study of dynamic cine CT angiography for the evaluation of abdominal aortic aneurysms: implications for endograft treatment.

Purpose: To utilize 40-slice electrocardiographically (ECG)-gated cine computed tomographic angiography (CTA) to characterize normal aortic motion during the cardiac cycle at relevant anatomical landmarks in preoperative abdominal aortic aneurysm (AAA) patients.

Methods: In 10 consecutive preoperative AAA patients (10 men; mean age 78.8 years, range 69-86), an ECG-gated CTA dataset was acquired on a 40-slice CT scanner using a standard radiation dose.