Efficacy of chronic amiodarone therapy in patients with variant angina pectoris and inhibition of ergonovine coronary constriction.

In three patients with vasospastic angina pectoris, chronic amiodarone administered orally at doses of 800 and 1,000 mg/day totally suppressed spontaneous episodes of ischemic chest pain for 8 to 14 months. Before treatment, ergonovine maleate 0.2 to 0.

Long-term management of sustained, recurrent, symptomatic ventricular tachycardia with amiodarone.

Twenty-three patients with sustained, recurrent, symptomatic ventricular tachycardia were treated with oral amiodarone. Initial doses were 600-2000 mg/day and maintenance doses were 200-1200 mg/day. Amiodarone was highly effective in 20 patients (87%), seven of whom had a follow-up of 30 months or longer, including two who were followed for 5 years.

Spontaneous remission in variant angina.

Four cases of variant angina are reported, in which total remission of anginal pain was documented during a follow-up of seven months, four years, five years, and 15 years, respectively. During this relatively long follow-up, the clinical course of the disease was apparently benign. The possibility of spontaneously and complete recovery may be postulated.