A protracted and aggressive variant of lymphocytic hypophysitis with mammillary body involvement and cognitive dysfunction.

Objective: Our objective was to describe the 14-year course of a patient with a protracted and aggressive variant of lymphocytic hypophysitis.

Methods: This is a case report.

Results: Despite several trials of pulse steroids, this young female patient demonstrated persistent inflammation of the pituitary gland with eventual extension into the mammillary bodies with clinical cognitive decline.