Neuropsychological and behavioural phenotype of Dandy-Walker variant presenting in chromosome 22 trisomy: a case study.

In this study, a case of Dandy-Walker variant syndrome associated with trisomy 22 in a 17-year-old man is described. This is the first account of this combination in a person surviving into adulthood, and the neuropsychological and behavioural presentation is described in detail and a clinical formulation is presented for the benefit of researchers and clinicians.

Think Effectively About Mood Swings (TEAMS): a case series of cognitive-behavioural therapy for bipolar disorders.

Background And Objectives: An integrative cognitive model for bipolar disorder proposes that multiple and extreme appraisals of changes in internal state and their reciprocal impact on behaviour, physiology and the environment provide the core mechanism in maintaining and escalating bipolar symptoms (Mansell, Morrison, Reid, Lowens, & Tai, 2007a).

Methods: A case series of cognitive-behavioural therapy (CBT) based on this model, known as the TEAMS approach (Think Effectively About Mood Swings), with seven participants was conducted. An A-B direct replication design with multiple baseline and follow-up assessments at one, three and six months was used.

Extreme positive and negative appraisals of activated states interact to discriminate bipolar disorder from unipolar depression and non-clinical controls.

Background: This research aimed to test whether positive, negative, or conflicting appraisals about activated mood states (e.g., energetic and high states) predicted bipolar disorder.