Intronic Variants in the (rs2303426 and rs10179950) and (rs2286681 and rs62456178) Genes Are Not Associated with Colorectal Cancer in Mexican Patients.

Background/objectives: In the origin and development of colorectal cancer (CRC), a global public health problem, a dysfunction mismatch repair system appears to be a key factor. The objective was to determine the association of intronic variants in the and genes with CRC in Mexican patients.

Methods: Blood samples of 143 CRC patients and 146 reference individuals were genotyped through TaqMan Genotyping Assays.

High frequency of MLH1 promoter methylation mediated by gender and age in colorectal tumors from Mexican patients.

Introduction: Several genes determine the development of colorectal cancer (CRC), such as MLH1, which encodes a protein that participates in DNA repair. MLH1 hypermethylation has been associated with gene silencing.

Objective: To analyze the methylation of five regions of MLH1 CpG island in colorectal tumors from Mexican patients.

Matrix metalloproteinases 7, 8, 12, 13 gene haplotypes associated with colorectal cancer in a Mexican population.

Background: Matrix metalloproteinases (MMPs) are involved in tumor invasion and progression in colorectal cancer (CRC). Variants rs11568818, rs11225395, rs2276109 and rs2252070 have been associated with this neoplasm.

Objective: To evaluate MMPs 7, 8, 12, and 13 haplotypes and their association with CRC.

Somatic deletion of gene is associated to advanced colorectal cancer stages.

Aims: KDM1A/LSD1 and ZNF217 are involved in a protein complex that participates in transcriptional regulation. has been analysed in numerous cancers and its amplification has been associated with advanced stages of disease; however, a similar role for has not been uncovered. In this study, we estimated the number of and gene copies in tissue samples from patients diagnosed with colorectal cancer (CRC), as well as its association with clinicopathological features in patients with CRC.