Two cases of combination therapy with cetuximab, paclitaxel, and cisplatin for advanced head and neck cancer.

Two patients diagnosed with advanced head and neck cancer were treated with cetuximab 400 mg/m intravenously for one loading dose followed by 250 mg/m IV on days 1, 8, and 15 along with paclitaxel 80 mg/m and cisplatin 30 mg/m intravenously on days 1 and 8 repeated every 21 days for three cycles (CPP). Maintenance cetuximab 250 mg/m intravenously weekly was continued following the aforementioned regimen for one year or until disease progression. Patient A was diagnosed with squamous cell carcinoma of the parotid gland treated initially with parotidectomy and radiation therapy.