Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis.

Introduction: Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predictor of poor outcome. In this study, we explored the impact of aging on the host response to sepsis using the fecal-induced peritonitis (FIP) model developed by the National Preclinical Sepsis Platform (NPSP).

Negative school experiences in early adolescence on depressive affect in middle adulthood.

This study takes a life course perspective to examine the long-term effect of negative school experiences during early adolescence on depressive affect in middle adulthood. The study uses a prospective longitudinal panel dataset that spanned nearly three decades with three waves: when respondents were at 7th grade (Time 1, mostly 12-13 years of age), young adulthood (Time 2, in their 20 s), and middle adulthood (Time 3, in their mid-30 s to early 40 s). The OLS regression models yielded results demonstrating that early negative school experiences were contemporaneously associated with depressive affect at Time 1, which endured through Time 2 and Time 3.

School performance, peer association, psychological and behavioral adjustments: a comparison between Chinese adolescents with and without siblings.

We test theoretically informed hypotheses using survey reports of adolescents attending three middle schools in the outskirts of Fuzhou, Fujian, China. Results yielded by regression analyses are quite consistent with the hypothesized relationships, that is, Chinese singleton adolescents are more likely to anticipate going to college than non-singleton adolescents. Further, singletons are more associated with conventional peers and they report better adjustments both psychologically and behaviorally than non-singleton adolescents.

Mediating Mechanisms for the Intergenerational Transmission of Constructive Parenting: A Prospective Longitudinal Study.

Based on a prospective longitudinal panel data set that was collected at three developmental stages-early adolescence, young adulthood, and middle adulthood- this study investigates marital satisfaction and educational attainment as mediating mechanisms as well as gender's moderating effect for the intergenerational transmission of constructive parenting (N = 1,560). The results show that perceived satisfying experiences with parents during early adolescence are positively related to marital satisfaction and educational attainment in young adulthood, which, in turn, are positively related to individuals' utilization of constructive parenting in middle adulthood. The two mediating mechanisms account for most of the direct effect of the intergenerational transmission of constructive parenting.

Near-infrared spectroscopy study of language activated hyper- and hypo-oxygenation in human prefrontal cortex.

Oxygenation changes in the left prefrontal cortex during language processing were assessed with near-infrared spectroscopy (NIRS). Oxyhemoglobin and deoxyhemoglobin concentrations at the Fp1 site during 5 min of resting with eyes closed (control), followed by 5 min of reading aloud, were monitored. A statistically significant change in the oxyhemoglobin concentration was observed by NIRS in all the subjects after execution of the experimental task.

Human cortical perfusion and the arterial pulse: a near-infrared spectroscopy study.

Background: The pulsatile nature of the arterial pulse induces a pulsatile perfusion pattern which can be observed in human cerebral cortex with non-invasive near-infrared spectroscopy. The present study attempts to establish a quantitative relation between these two events, even in situations of very weak signal-to-noise ratio in the cortical perfusion signal. The arterial pulse pattern was extracted from the left middle finger by means of plethesmographic techniques.

The nongroup market as one element of a broader coverage-expansion strategy.

Effective health insurance provides financial protection and access to services that maintain and improve health. Such coverage is difficult to obtain in the nongroup market, however, because of a lack of sponsorship, the nature of coverage available, adverse selection, and high administrative costs. However, certain interventions could make this market an effective avenue for expanding coverage to moderate- to high-income persons who lack access to employer-based coverage.