Publications by authors named "Ruth Kemper"
Clin Pharmacokinet
December 2024
Article Synopsis
- The study aimed to analyze how paracetamol and its metabolites behave in extremely preterm neonates during treatment for patent ductus arteriosus and to identify factors influencing variability in individual responses.
- Thirty preterm neonates receiving paracetamol were monitored, revealing that the drug was mostly metabolized through the sulfation pathway, which decreased with gestational age, while the glucuronidation pathway increased.
- The results showed no link between the level of drug exposure and clinical outcomes or liver function indicators, suggesting that the dosages used might already achieve optimal effectiveness for ductus closure.
