The prevalence of frailty among acute stroke patients, and evaluation of method of assessment.

Objective: We aimed to determine prevalence of pre-stroke frailty in acute stroke and describe validity of a Frailty Index-based assessment.

Design: Cross-sectional.

Setting: Single UK urban teaching hospital.

Pre-Stroke Frailty Is Independently Associated With Post-Stroke Cognition: A Cross-Sectional Study.

Objective: Post-stroke cognitive impairment is common, but mechanisms and risk factors are poorly understood. Frailty may be an important risk factor for cognitive impairment after stroke. We investigated the association between pre-stroke frailty and acute post-stoke cognition.

Comparison of surface-enhanced resonance Raman scattering and fluorescence for detection of a labeled antibody.

A comparison is made of the quantitative detection of a labeled antibody by surface-enhanced resonance Raman scattering (SERRS) and by fluorescence using the same instrument with the same laser excitation source. The area under the curve for the fluorescence band is greater than for any single peak in the SERRS spectrum, but the broad fluorescence band is more difficult to discriminate from the background at low concentrations. Using the peak height of one SERRS band and the peak height at the fluorescence maximum, the detection limit for SERRS was lower (1.

Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease.

COPD is a major cause of mortality in the western world. A(2A) agonists are postulated to reduce the lung inflammation that causes COPD. The cardiovascular effects of A(2A) agonists dictate that a compound needs to be delivered by inhalation to be therapeutically useful.

The first SERRS multiplexing from labelled oligonucleotides in a microfluidics lab-on-a-chip.

The first simultaneous detection of three dye-labelled oligonucleotides in a microfluidics chip by SERRS is reported.

Selective functionalisation of TNT for sensitive detection by SERRS.

Selective chemical functionalisation of 2,4,6-trinitrotoluene to a surface enhanced resonance Raman active species for sensitive detection.

SERRS. In situ substrate formation and improved detection using microfluidics.

Surface-enhanced resonance Raman scattering (SERRS) of a model derivative of TNT was detected using a microflow cell designed within the framework of the lab-on-a-chip concept, using only the analyte and readily available reagents. The SERRS substrate, silver colloid, was prepared in situ, on-chip, by borohydride reduction of silver nitrate. The silver colloid was imaged within the chip using a white light microscope in either transmission or, due to the high reflectivity of the colloid, reflection mode.