Publications by authors named "Ruth Hong"
Article Synopsis
- Maintaining protein homeostasis is crucial for cell health, and research has identified a signaling pathway from mitochondria to the cytosol that helps improve proteostasis when mitochondrial function is disrupted.
- This study reveals a new interaction between mitochondria and the endoplasmic reticulum (ER), called the Mitochondria to ER Stress Response (MERSR), which impacts the unfolded protein response (UPR) by inhibiting its IRE1 branch.
- The activation of MERSR enhances proteostasis through the PERK-eIF2α pathway, leading to better handling of protein aggregates in disease models, suggesting a coordinated effort between mitochondria and ER to maintain cellular health.
