Publications by authors named "Ruth HallSedlak"
The Vetscan Imagyst system (Zoetis) is a novel, artificial intelligence-driven detection tool that can assist veterinarians in the identification of enteric parasites in dogs and cats. This system consists of a sample preparation device, an automated digital microscope scanner, and a deep-learning algorithm. The EasyScan One scanner (Motic) has had good diagnostic performance compared with manual examinations by experts; however, there are drawbacks when used in veterinary practices in which space for equipment is often limited.
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- Human herpesvirus 6 (HHV-6) can integrate into chromosomes and be inherited through gametes, which leads to its presence in nearly every cell of individuals who have it.
- A study analyzed 4319 pairs of hematopoietic cell transplant (HCT) donors and recipients to understand the impact of inherited chromosomally integrated HHV-6 (iciHHV-6) on post-transplant outcomes.
- The presence of iciHHV-6 was linked to a higher risk of acute graft-versus-host disease and increased cytomegalovirus viremia, but did not significantly impact other outcomes like chronic GVHD or overall mortality, suggesting the potential for using iciHHV-6 screening in donor selection and
Human herpesviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telomeres of human chromosomes. The viral and cellular factors contributing to HHV-6A/B integration remain largely unknown, mostly due to the lack of efficient and reproducible cell culture models to study HHV-6A/B integration. In this study, we characterized the HHV-6A/B integration efficiencies in several human cell lines using two different approaches.
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- Human herpesvirus 6 (HHV-6) can integrate into chromosomes and is inherited in about 1% of the population through germ cells, potentially affecting human health.
- A group testing approach was implemented to identify individuals with inherited ciHHV-6 by screening 2496 cellular samples from hematopoietic cell transplant (HCT) pairs, using advanced molecular techniques.
- This efficient testing method confirmed inherited ciHHV-6 in a small percentage of donors and recipients, paving the way for larger studies on the clinical significance of this condition.