An Unsymmetric Ligand Framework for Noncoupled Homo- and Heterobimetallic Complexes.

We introduce a new unsymmetric ligand, PDIpCy (PDI = pyridyldiimine; Cy = cyclam), that offers two distinct, noncoupled coordination sites. A series of homo- and heterobimetallic complexes, [Zn(PDIpCy)(THF)(OTf)] (1; THF = tetrahydrofuran and OTf = triflate), [Ni(PDIpCy)(THF)(OTf)](OTf) (2), and [NiZn(PDIpCy)(THF)(OTf)] (3), are described. The one-electron-reduced compounds, [Zn(PDIpCy)(OTF)] (4), [Ni(PDIpCy)(OTf)](OTf) (5), and [NiZn(PDIpCy)(OTf)] (6), were isolated, and their electronic structures were characterized.

A double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [C]-basimglurant and absolute bioavailability after oral administration and concomitant intravenous microdose administration of [C]-labeled basimglurant in humans.

1. The emerging technique of employing intravenous microdose administration of an isotope tracer concomitantly with an [C]-labeled oral dose was used to characterize the disposition and absolute bioavailability of a novel metabotropic glutamate 5 (mGlu5) receptor antagonist under clinical development for major depressive disorder (MDD). 2.