Publications by authors named "Ruth Feilcke"
Methicillin-resistant (MRSA) infections are still a major problem in hospitals. The excellent safety profile, accessibility and anti-infective activity of tea extracts make them promising agents for the treatment of infected wounds. To investigate the possibility of sterilising MRSA-infected surfaces, including skin with tea extracts, we determined the MICs for different extracts from green and black tea (), including epigallocatechin gallate (EGCG), on a large number of clinical isolates of MRSA, selected to represent a high genetic diversity.
View Article and Find Full Text PDFA sterilizing or functional cure for HIV is currently precluded by resting CD4 T cells that harbor latent but replication-competent provirus. The "shock-and-kill" pharmacological ap-proach aims to reactivate provirus expression in the presence of antiretroviral therapy and target virus-expressing cells for elimination. However, no latency reversal agent (LRA) to date effectively clears viral reservoirs in humans, suggesting a need for new LRAs and LRA combinations.
View Article and Find Full Text PDFArticle Synopsis
- * Knipholone showed strong cytotoxic effects on certain cancer cells, while knipholone anthrone had a range of effectiveness, achieving up to 70% growth inhibition in some cell lines.
- * The stability study revealed that knipholone anthrone oxidizes quickly in culture media, converting into knipholone, which suggests that the biological effects attributed to anthrone could be affected by its unstable nature and degradation products.