Publications by authors named "Ruth E Siddorn"
Article Synopsis
- Striatal dopamine (DA) is essential for regulating action and learning, with recent findings indicating that its release is inhibited by GABA in the striatum.
- The role of plasma membrane GABA uptake transporters (GATs), particularly GAT-1 and GAT-3 located on astrocytes and neurons, in influencing DA output has emerged as a key focus of the research.
- In a mouse model of early parkinsonism, reduced GAT levels lead to increased inhibition of DA release and highlight maladaptive changes affecting DA output in critical regions of the striatum.
Article Synopsis
- Nigrostriatal dopamine (DA) plays an essential role in action selection and learning, and its release is influenced by various striatal neurotransmitters, primarily GABA and cholinergic interneurons (ChIs).
- Research indicates that GABA can directly inhibit DA release in the striatum through GABA receptors, independent of ChI activity, as demonstrated through experiments with male mice striatal slices.
- Findings suggest that GABA and its receptors provide tonic inhibition of DA release, indicating a significant regulatory role for striatal GABA in dopamine signaling.
