Structural birth defects associated with omphalocele and gastroschisis, Hawaii, 1986-2001.

There is limited information on the specific structural birth defects associated with the abdominal wall defects (AWD) omphalocele and gastroschisis, particularly which defects occur with the AWD at greater than expected rates (rates among all infants and fetuses with birth defects other than the AWD). Using data from a population-based birth defects registry in Hawaii, this study calculated the rates for 48 specific structural birth defects among the AWD and compared these rates to the expected rates. There were 60 cases of omphalocele, 96 cases of gastroschisis, and 12,161 infants and fetuses with structural birth defects excluding the AWD among deliveries during 1986-2001.

Precurrence risk of birth defects in Hawaii.

The aim of the investigation was to describe the risk of selected types of birth defects among older siblings of infants and fetuses with specific birth defects. Using data from a population-based birth defects registry in Hawaii for deliveries during 1986-2000, the precurrence risk (risk among older siblings) for any major birth defect, birth defects of the same organ system, and same specific birth defect were calculated for nine major organ systems and 54 specific birth defects. The precurrence risk of any major birth defect (3.

Comparison of cleft lip only and cleft lip and palate, Hawai'i, 1986-2003.

Using birth defects registry data, this investigation compared cleft lip only (CLO) and cleft lip and palate (CLP). CLP cases were more likely than CLO cases to expire after birth (3.2% versus 1.

Structural birth defects associated with neural tube defects in Hawai'i from 1986 until 2001.

Using birth defects registry data, this study identified birth defects associated with anencephaly, spina bifida, and encephalocele. Musculoskeletal defects were associated with anencephaly; central nervous system defects, gastrointestinal atresia/stenosis, genitourinary system defects, and musculoskeletal system defects with spina bifida; and central nervous system defects, respiratory defects, oral clefts, genitourinary system defects, and musculoskeletal system defects with encephalocele.

Pattern of chromosomal inversions identified by a birth defects registry, Hawaii, 1986-2002.

The aim of the investigation was to describe chromosomal inversions identified by a birth defects registry with respect to chromosomes involved, pregnancy outcome, method of diagnosis, inheritance, sex and diagnosis of major structural birth defects. Cases were derived from a population-based birth defects registry in Hawaii and comprised all infants and fetuses with chromosomal deletions delivered during 1986-2002. A total of 68 cases were identified through a statewide birth defects registry in Hawaii during 1986-2002.

Patterns of chromosomal deletions identified by a birth defects registry, Hawaii, 1986-2003.

The aim of the investigation was to describe the chromosomal deletions identified by a birth defects registry with respect to the chromosomes involved, pregnancy outcome, method of diagnosis, inheritance, sex, and the diagnosis of major structural birth defects. Cases were derived from a population-based birth defects registry in Hawaii and comprised all infants and fetuses with chromosomal deletions delivered during 1986-2003. A total of 71 cases were identified through a statewide birth defects registry in Hawaii during 1986-2003.

Genetic counseling utilization by families with offspring affected by birth defects, Hawaii, 1986-2003.

Information on the genetic counseling facility utilization by families with offspring affected by birth defects in the United States is limited. The intent of this study was to report on genetic counseling utilization in Hawaii. Cases were all infants and fetuses of any pregnancy outcome with major birth defects included in a Hawaii birth defects registry and delivered during 1986-2003.

Potential impact of pregnancy outcome on the completeness of diagnosis of birth defects, Hawai'i, 1986-2001.

Using data from a birth defects registry, this study investigated whether pregnancy outcome influences completeness of diagnosis ascertainment for cases with seven selected birth defects. For anencephaly, spina bifida, encephalocele, trisomy 21, trisomy 13, and trisomy 18, the proportion of isolated cases was higher among elective terminations than among live births. This was not the situation for omphalocele.

Pattern of birth defects delivered to non-residents in Hawai'i, 1986-2002.

Using birth defects registry data, this study examined whether deliveries to residents and non-residents differed. The non-resident rate was significantly higher among those infants/fetuses with more than one major birth defect, pregnancy outcomes that did not result in live births, multiple births, deliveries in the City and County of Honolulu, and pregnancies where prenatal diagnostic procedures had been performed.

Risk of selected birth defects with prenatal illicit drug use, Hawaii, 1986-2002.

The literature on the association between prenatal illicit drug use and birth defects is inconsistent. The objective of this study was to determine the risk of a variety of birth defects with prenatal illicit drug use. Data were derived from an active, population-based adverse pregnancy outcome registry.

Descriptive epidemiology of hemivertebrae, Hawaii, 1986-2002.

The intent of this study was to report on the epidemiology of hemivertebrae. Cases were derived from a population-based birth defects registry in Hawaii and comprised all infants and fetuses with hemivertebrae delivered during 1986-2002. Hemivertebrae rates per 10 000 births were determined for selected factors and comparisons made by calculating the rate ratio (RR) and 95% confidence interval (CI).

Use of prenatal diagnostic procedures in pregnancies affected with birth defects, Hawaii, 1986-2002.

Background: Information on the utilization of prenatal ultrasound (US), amniocentesis (AC), and chorionic villus sampling (CVS) in pregnancies affected by birth defects in the United States is limited. The intent of this study was to report on the utilization of these procedures in Hawaii.

Methods: Cases were all infants and fetuses of any pregnancy outcome with birth defects, included in a Hawaii birth defects registry, and delivered during 1986-2002.

Comparison of trends in gastroschisis and prenatal illicit drug use rates.

Gastroschisis rates have been increasing over time, and gastroschisis risk is elevated in women of young maternal age. Similar patterns were reported for prenatal illicit drug use in Hawaii. Cases of gastroschisis and prenatal use of methamphetamine, cocaine, or marijuana among deliveries in Hawaii during 1986-2002 were identified from a common registry.

Rates for specific birth defects among offspring of Japanese mothers, Hawaii, 1986-2002.

The objective of this investigation was to identify the rates for specific birth defects among the offspring of Japanese mothers in Hawaii and compare them to rates among the offspring of white mothers. Cases were all infants and fetuses with any of 54 specific birth defects born to Japanese and white mothers identified by a population-based birth defects registry in Hawaii. The rates were calculated for both racial groups and comparisons made by calculating the rate ratio and 95% confidence interval.

Structural birth defects associated with oral clefts in Hawaii, 1986 to 2001.

Objective: To identify structural birth defects that occur in association with oral clefts.

Methods: Data were obtained from a birth defects registry and included all infants and fetuses with cleft palate without cleft lip or cleft lip with or without cleft palate delivered from 1986 to 2001. For 47 specific structural birth defects, rates among oral cleft cases were compared with the rates among all infants and fetuses with major birth defects, excluding those with oral clefts.

Descriptive epidemiology of anophthalmia and microphthalmia, Hawaii, 1986-2001.

Background: Population-based epidemiologic data on anophthalmia and microphthalmia in the United States are limited and have come mainly from only a few states. The intent of this study was to report on the epidemiology of these eye defects.

Methods: Cases were derived from a population-based birth defects registry in Hawaii and comprised all infants and fetuses with anophthalmia and microphthalmia who were delivered during 1986-2001.

Rates of selected birth defects in relation to folic acid fortification, Hawaii, 1986-2002.

Because of studies suggesting that folic acid use reduces risk of various birth defects, the Unites States fortified enriched cereal grains with folic acid in 1998. To determine whether this fortification reduced rates for birth defects in Hawaii, rates were calculated before and after fortification. Of the 19 birth defects categories studied, the rates for 16 were lower after fortification.

Descriptive epidemiology of teratoma in infants, Hawaii, 1986-2001.

Although teratoma is the most common type of neonatal tumour, there are few population-based epidemiological data on teratoma among infants. Using data from a population-based birth defects registry in Hawaii, this study described the distribution of teratoma with respect to various demographic and clinical factors. A total of 22 cases were identified among deliveries in 1986-2001, of which 13 (59.

Descriptive epidemiology of anotia and microtia, Hawaii, 1986-2002.

The objective of this investigation was to describe the epidemiology of anotia and microtia with respect to various factors. The cases studied were all infants and fetuses with anotia or microtia identified by a population-based birth defects registry in Hawaii. The anotia and microtia rates were determined for selected factors and comparisons made among the subgroups by calculating the rate ratio (RR) and 95% confidence interval (CI).

Descriptive epidemiology of congenital hydrocephaly in Hawaii, 1986--2000.

Using data from a birth defects registry, this study examined the epidemiology of hydrocephaly in Hawaii during 1986--2000. There were 294 cases of hydrocephaly, resulting in a rate of 10.4 per 10,000 live births.

Descriptive epidemiology of lipomyelomeningocele, Hawaii, 1986-2001.

Background: The epidemiology of neural tube defects (NTDs) may depend on the type of the defect and its location. There is little epidemiologic information on lipomyelomeningocele, a type of NTD. The objective of this investigation was to describe the epidemiology of lipomyelomeningocele.

Descriptive epidemiology of selected congenital heart defects, Hawaii, 1986-1999.

Congenital heart defects are the most common type of birth defect and contribute the most to infant mortality due to birth defects. This study examined the relationship between several demographic factors and selected congenital heart defects among the unique multiethnic population in Hawaii during 1986-99, using data from a population-based birth defects registry. Rates were significantly higher in 1993-99 than in 1986-92 for transposition of the great arteries and Ebstein's anomaly, and significantly lower for tetralogy of Fallot.

Descriptive epidemiology of oral clefts in a multiethnic population, Hawaii, 1986-2000.

Objective: To describe the relationship between oral clefts and demographic and clinical factors in Hawaii.

Methods: Data were obtained from a birth defects registry and included all infants and fetuses with oral clefts delivered during 1986 through 2000. Subjects were categorized as total, isolated, and nonisolated cleft lip with or without cleft palate (CL+/-P) or cleft palate without cleft lip (CP).

Rates for specific birth defects among native Hawaiians compared to whites, Hawaii 1986-2000.

Rates for many birth defects have not been identified for native Hawaiians. Using birth defects regstry data, the total major birth defect rate for whites was found to be 4.70% and for native Hawaiians was 4.