Publications by authors named "Ruth Carbone"
Article Synopsis
- The study analyzes bacteremia and antibiotic resistance in Gram-negative bacilli among patients with hematological malignancies and those undergoing hematopoietic stem cell transplants across different geographic regions.
- It includes 1,277 cases of bacteremia, revealing that Gram-negative bacilli were present in 60.3% of episodes, with a notable occurrence of multidrug-resistant organisms (MDROs) affecting 40.2% of these infections.
- Key risk factors for 30-day mortality identified include relapse of underlying disease, use of corticosteroids, and the presence of resistant bacteria, emphasizing the high mortality associated with carbapenem-resistant cases.
Seven-day antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients: toward a new paradigm.
Eur J Clin Microbiol Infect Dis
September 2024
Purpose: Data on short courses of antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients are limited. The aim of the study was to describe and compare the frequency of bacteremia relapse, 30-day overall and infection-related mortality, Clostridiodes difficile infection and length of hospital stay since bacteremia among those who received antibiotic therapy for 7 or 14 days.
Methods: This is a multicenter, prospective, observational cohort study in adult high-risk neutropenic patients with hematologic malignancies or hematopoietic stem cell transplant and monomicrobial Enterobacterales bacteremia.
Identifying the risk factors for carbapenem-resistant Enterobacterales (CRE) bacteremia in cancer and hematopoietic stem cell transplantation (HSCT) patients would allow earlier initiation of an appropriate empirical antibiotic treatment. This is a prospective multicenter observational study in patients from 12 centers in Argentina, who presented with cancer or hematopoietic stem-cell transplant and developed Enterobacterales bacteremia. A multiple logistic regression model identified risk factors for CRE bacteremia, and a score was developed according to the regression coefficient.
View Article and Find Full Text PDF