Publications by authors named "Ruth C Richards"
Article Synopsis
- Lipid droplets (LDs) serve as vital organelles for storing energy and regulating lipid levels in cells.
- Researchers discovered that a protein called spartin acts as a receptor for LDs and is essential for their breakdown through a process called lipophagy, which involves delivering LDs to lysosomes.
- Mutations in the spartin gene are linked to Troyer syndrome, indicating that the inability to properly degrade LDs may play a role in the development of this hereditary condition.
Haploinsufficiency of GRN causes frontotemporal dementia (FTD). The GRN locus produces progranulin (PGRN), which is cleaved to lysosomal granulin polypeptides. The function of lysosomal granulins and why their absence causes neurodegeneration are unclear.
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