A clinical evaluation of a novel algorithm in the reliable detection of epileptic seizures.

Purpose: Undetected and prolonged epileptic seizures can result in hypoxic brain damage or death and occur most often when the victim is in bed alone or unsupervised. Sudden unexpected death in epilepsy may not always be preventable but it is believed that timely assistance with rescue medication and body re-positioning may overcome respiratory compromise in some cases. A novel algorithm based on a real time moving 9 s epoch, calculating 25 % percentage heart rate change and/or an oxygen saturation trigger level of <85 % was developed using photoplethysmography and incorporated into a prototype data storage device.

Parasympathetic alteration during sub-clinical seizures.

Introduction: Autonomic instability is considered a contributing factor in sudden unexpected death in epilepsy (SUDEP). The aim of this pilot study was to measure parasympathetic activity in sub-clinical seizures to investigate autonomic instability.

Materials And Methods: A prospective study based on Video-electroencephalography (EEG)/electrocardiography (ECG)/oxygen saturation (SAO2) recordings was selected from patients having sub-clinical seizures during stage 3 or 4 sleep.

Lengthening of corrected QT during epileptic seizures.

Purpose: To measure the corrected QT cardiac repolarization time before and during epileptic seizures.

Methods: Thirty-nine video-EEG/ECG/SAO(2) (electroencephalography/electrocardiography/oxygen saturation) telemetry patients were included in this prospective study. Epileptic seizures were identified both clinically and electrographically.