Publications by authors named "Ruth Axer-Siegel"
Purpose: To compare intra- and postoperative complications in combined phacoemulsification and pars plana vitrectomy surgeries performed in patients with non-proliferative diabetic retinopathy (NPDR) vs. proliferative diabetic retinopathy (PDR).
Methods: Retrospective, case series of patients with diabetic retinopathy who underwent combined phacovitrectomy surgery between 2008 and 2017.
Article Synopsis
- The study aimed to evaluate the foveal microvascular structure in children who had retinopathy of prematurity (ROP) and were treated with diode laser photocoagulation, utilizing optical coherence tomography angiography (OCTA).
- The research involved 17 children with a history of ROP and compared their OCTA results to those of 12 healthy controls, finding significant differences in several parameters.
- Key findings included a smaller foveal avascular zone and lower vascular density in the ROP group, indicating that OCTA can reveal important long-term changes in macular structures for these patients.
Aim: To determine the rate and possible contributors for post-pars plana vitrectomy (PPV) epiretinal membrane (ERM) in patients treated for rhegmatogenous retinal detachment (RRD).
Methods: This prospective, nonrandomized study comprised 47 consecutive patients (47 eyes) with acute RRD treated with 23 G post-PPV. All participants were followed prospectively for 6mo for the development of ERM using spectral domain optical coherence tomography.
Article Synopsis
- The study aimed to assess protein levels involved in coagulation, inflammation, and angiogenesis in the vitreous fluid of patients with different eye conditions.
- It involved collecting vitreous samples from patients undergoing vitrectomy for issues like retinal detachment, comparing them to control groups with macular hole and epiretinal membrane.
- Findings showed that patients with proliferative diabetic retinopathy (PDR) had notably higher levels of several proteins linked to coagulation and inflammation, indicating a strong correlation between these pathways in the context of PDR.
Effect of Subretinal Fluid Drainage Using Perfluorocarbon During Retinal Detachment Repair on Postoperative Metamorphopsia.
Ophthalmic Surg Lasers Imaging Retina
December 2018
Background And Objective: To determine whether subretinal fluid drainage (SRF) using perfluorocarbon (PFC) during rhegmatogenous retinal detachment (RRD) repair reduces postoperative metamorphopsia.
Patients And Methods: Consecutive patients after RRD were evaluated for best-corrected visual acuity (BCVA), funduscopy, and metamorphopsia using M-CHARTS. Fundus autofluorescence and optical coherence tomography were performed.
Purpose: To model and analyse the ocular biometry of new-born infants.
Methods: This work is based on previously published data of a cohort of 66 new-born infants aged 0-3 days. After exclusion of seven myopic subjects, the available retinoscopy, keratometry and ultrasound biometry data were analysed, along with calculated parameters such as lens power and whole eye power.
Article Synopsis
- The study examines the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous fluid of patients with various eye conditions to understand their correlation.
- 78 patients were grouped based on their vitreoretinal issues (macular hole/epiretinal membrane, retinal detachment, and diabetic retinopathy), and their IL-6 and TAT levels were measured and compared.
- Findings show significant differences in IL-6 and TAT levels among groups, with diabetes linked to higher IL-6 in retinal detachment cases, indicating that TAT levels may differ due to inflammation and specific eye tissue responses.
Article Synopsis
- The study investigated the effectiveness of using perfluorocarbon heavy liquid as a temporary tamponade for patients with giant retinal tears after vitrectomy, involving 13 patients treated between 2011 and 2015.
- All patients achieved retinal reattachment during surgery, with a follow-up period showing that the retina remained attached in all cases, although one patient experienced complications requiring additional surgery.
- Postoperative visual acuity improved, especially in patients with macula-off detachments, indicating perfluorocarbon heavy liquid is a safe and effective option for this procedure.
Photodynamic Therapy for Pseudophakic Eyes Compared to Eyes With Cataract.
Ophthalmic Surg Lasers Imaging Retina
December 2016
Background And Objective: Verteporfin photodynamic therapy (vPDT) plays a role in the treatment of chorioretinal conditions. The purpose of this study was to compare vPDT outcomes between cataractous and pseudophakic eyes.
Patients And Methods: In this prospective study of consecutive patients with choroidal neovascularization (CNV) secondary to neovascular age-related macular degeneration (nAMD) treated with vPDT, cataract and pseudophakic eyes were compared for number and timing of vPDT treatments, duration of follow-up, angiographic features, and changes in best-corrected visual acuity (BCVA).
Purpose: To investigate the response to intravitreal ranibizumab after failure of intravitreal bevacizumab in patients with diabetic macular edema (DME).
Methods: Demographics, visual acuity (VA), central macular thickness (CMT), and HbA1C were retrospectively collected from DME patients treated with second-line intravitreal ranibizumab at a tertiary hospital in 2012-2013 and followed for at least 3 months.
Results: Twenty-two patients (26 eyes) were included in the study, with a mean (±SD) age of 66 ± 8.
Purpose: To evaluate the outcomes and complications of patients with diabetic tractional retinal detachment (TRD) treated with pars plana vitrectomy (PPV).
Patients And Methods: We retrospectively studied a case series of 24 eyes of 21 patients at a single tertiary, university-affiliated medical center. A review was carried out on patients who underwent PPV for the management of TRD due to proliferative diabetic retinopathy from October 2011 to November 2013.
Intracameral cefuroxime and the incidence of post-cataract endophthalmitis: an Israeli experience.
Graefes Arch Clin Exp Ophthalmol
October 2015
Purpose: The European Society of Cataract & Refractive Surgeons (ESCRS) study reported a decrease in endophthalmitis rates from 0.34 % to 0.08 % with the use of intracameral cefuroxime.
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- The study aimed to see if the time it takes to normalize increased intracranial pressure (ICP) due to intraventricular hemorrhage (IVH) affects treatment for retinopathy of prematurity (ROP) in premature infants.
- Researchers reviewed medical records of premature infants (≤ 35 weeks gestation or ≤ 1500g birth weight) who had both ROP and IVH, comparing those treated for only ICP versus those treated for both conditions.
- Results showed that infants treated for both ROP and ICP took longer to normalize ICP (100 days) compared to those treated for ICP alone (45 days), suggesting that quicker management of ICP might lessen the need for ROP treatment.
Objective: To evaluate long-term safety of intravitreal ranibizumab 0.5-mg injections in neovascular age-related macular degeneration (nAMD).
Design: Twenty-four-month, open-label, multicenter, phase IV extension study.
Purpose: To investigate the effect of intravitreal bevacizumab on the visual and anatomic outcome of patients with exudative age-related macular degeneration presenting with good visual acuity (VA).
Methods: A file review was performed for all consecutive patients with newly diagnosed exudative age-related macular degeneration and initial VA of ≥ 20/40 treated in 2005 to 2010 and followed for at least 6 months. Treatment consisted of 3 loading doses of intravitreal bevacizumab every 6 weeks and was repeated when fluid or hemorrhage was present.
Purpose: To investigate the visual and anatomical effects of intravitreal bevacizumab treatment of macular edema due to central retinal vein occlusion (CRVO).
Methods: Data were collected by medical chart review for 35 consecutive patients (35 eyes) with CRVO-induced macular edema treated with intravitreal bevacizumab in 2007-2010 and followed for at least 6 months. All patients received 3-4 loading doses (1.
Purpose: To report the functional and anatomical outcome of intravitreal bevacizumab (IVB) treatment for macular edema due to branch retinal vein occlusion (BRVO) in a clinical setting.
Methods: The files of 45 patients treated with IVB for BRVO-induced macular edema at a tertiary medical center in 2007-2010 were reviewed. All received three loading doses (1.
Background: To investigate the role of inflammation in age-related macular degeneration by measuring the levels of cytokines in the aqueous humour.
Methods: Samples of aqueous humour were collected from 34 patients with age-related macular degeneration and 16 age-matched control subjects undergoing cataract surgery. Age-related macular degeneration stage was determined clinically, before surgery.
Purpose: There are 2 common alleles for Hp (Hp-1 and Hp-2) and 3 common Hp genotypes: Hp1-1, Hp2-1, and Hp2-2. The haptoglobin genotype may play a dual role in morbidities of diabetes: Hp1-1, protective and Hp2-2, provocative. This study investigated the possible association of haptoglobin genotypes with onset of retinopathy in Type 2 diabetes (DM2).
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- The study examines the effectiveness of intravitreal bevacizumab as either a main or additional treatment for severe retinopathy of prematurity in infants.
- Nine infants with severe cases were analyzed; they had varying levels of gestational age and birth weight, and required treatment due to progression despite laser therapies.
- Results showed that bevacizumab successfully reduced active blood vessel growth in all treated eyes, with favorable anatomical outcomes and no significant complications reported.
Objective: To demonstrate noninferiority of a quarterly treatment regimen to a monthly regimen of ranibizumab in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
Design: A 12-month, multicenter, randomized, double-masked, active-controlled, phase IIIb study.
Participants: Patients with primary or recurrent subfoveal CNV secondary to AMD (353 patients), with predominantly classic, minimally classic, or occult (no classic component) lesions.
Article Synopsis
- The study aimed to assess how effective a sub-Tenon's block with ropivacaine is in reducing post-operative pain after strabismus surgery, a procedure that can cause significant discomfort.
- Conducted on 79 patients aged 1 to 65, half received the anesthetic at the end of surgery, and pain levels were measured using a visual analog scale at various times after the procedure.
- Results showed that patients who received the ropivacaine block experienced significantly less pain 12-16 hours post-surgery, required fewer additional painkillers, and reported higher satisfaction compared to those who did not receive the block.
Article Synopsis
- The study aimed to identify when the oculocephalic reflex is suppressed in infants and how it relates to clinical factors like age and weight.
- Conducted on 325 healthy babies, the reflex was tested by moving their heads and observing eye movements, determining that 75% had the reflex suppressed by 11.5 weeks.
- Results indicated that postpartum age was the most significant factor influencing the suppression, and the reflex’s disappearance is a normal part of visual system maturation.*
Purpose: The purpose of this study was to report our experience with intravitreal bevacizumab for inflammation-related choroidal neovascularization in two tertiary centers.
Methods: This study was a retrospective analysis of patients with choroidal neovascularization related to inflammatory diseases, treated with intravitreal bevacizumab injections (1.25 mg/0.