Publications by authors named "Ruth Anne Franklin"
Article Synopsis
- Myeloid cells, specifically macrophages, play a crucial role in regulating inflammation in synovial joints, particularly in rheumatoid arthritis, where the molecule IL-34 is significantly expressed.
- IL-34 interacts with a newly identified receptor called PTPRZ found on macrophages, and their absence in specific mouse models led to more severe arthritis symptoms.
- IL-34 and PTPRZ work to promote a reparative macrophage phenotype, enhancing the clearance of dying neutrophils and reducing their recruitment to the inflamed joint, ultimately limiting destructive inflammation and joint damage.
