Publications by authors named "Rutaraj Patil"
J Appl Genet
November 2019
Article Synopsis
- - The study investigates the effects of hydroxypropyl-beta-cyclodextrin (HPBCD) on olfaction and neural stem cell counts in models of Niemann-Pick C1 (NPC1) disease, which is characterized by olfactory defects in Npc1-null and Npc1 hypomorph mice.
- - Npc1 homozygous mice showed significant delays in finding food compared to wild-type mice and had early loss of olfaction; HPBCD treatment improved olfaction and increased neural stem cells in mutants but not in wild-types.
- - Nasal delivery of HPBCD, despite being less effective in improving olfaction than systemic delivery, led to temporary delays in olfactory loss for
