Publications by authors named "Rut Andrea"
Article Synopsis
- The Shock-CAT study aimed to assess in-hospital mortality and prognosis in cardiogenic shock (CS) patients, comparing those with acute myocardial infarction (AMI) to those without it.
- Out of 382 patients studied, AMI-CS exhibited higher in-hospital mortality rates (37.1%) compared to non-AMI-CS (26.7%), with AMI-CS patients requiring more mechanical circulatory support.
- The IABP-SHOCK II score was found to be more accurate than the CardShock score in predicting 90-day mortality for AMI-CS patients, while both scores performed similarly for non-AMI-CS patients.
Background: Retrospective studies support that mean perfusion pressure (MPP) deficit in cardiac surgery patients is associated with a higher incidence of acute kidney injury (CS-AKI). The aim of our study was to apply an algorithm based on MPP in the postoperative period to determine whether management with an individualized target reduces the incidence of CS-AKI.
Methods: Randomized controlled trial of patients undergoing cardiac surgery with extracorporeal circulation.
Objectives: The venous-to-arterial CO2 partial pressure difference (CO2) is a marker of how adequately capillary blood flow is able to remove CO2 from tissues, but evidence regarding its usefulness in patients with cardiogenic shock (CS) is scarce The main objective of this study was to describe the changes in CO2 in patients with cardiogenic shock during the 48 hours after hospital admission. A secondary objective was to analyze the association between CO2 and in-hospital mortality due to cardiovascular disease (CVD) and cardiogenic shock refractory to treatment.
Material And Methods: Prospective observational exploratory study in a single hospital.
Aim: To determine long-term survival of patients after cardiac arrest undergoing emergent coronary angiography and therapeutic hypothermia.
Methods: We analysed data from patients treated within the regional STEMI Network from January 2015 to December 2020. The primary endpoint was all-cause mortality at median follow-up.
Introduction: Prediction of recurrent ventricular arrhythmia (VA) in survivors of an out-of-hospital cardiac arrest (OHCA) is important, but currently difficult. Risk of recurrence may be related to presence of myocardial scarring assessed with late gadolinium enhancement cardiac magnetic resonance (LGE-CMR). Our study aims to characterize myocardial scarring as defined by LGE-CMR in survivors of a VA-OHCA and investigate its potential role in the risk of new VA events.
View Article and Find Full Text PDFBackground: Center-based cardiac rehabilitation programs (CRPs) reduce morbidity and mortality after an ischemic cardiac event; however, they are widely underused. Home-based CRP has emerged as an alternative to improve patient adherence; however, its safety and efficacy remain unclear, especially for older patients and female patients.
Objective: This study aimed to develop a holistic home-based CRP for patients with ischemic heart disease and evaluate its safety and impact on functional capacity, adherence to a healthy lifestyle, and quality of life.
Heart failure (HF) is classified according to the degree of reduction in left ventricular ejection fraction (EF) in HF with reduced, mildly reduced, and preserved EF. Biomarkers could behave differently depending on EF type. Here, we analyze the soluble form of the AXL receptor tyrosine kinase (sAXL) in HF patients with reduced and preserved EF.
View Article and Find Full Text PDFPerformance analysis of a STEMI network: prognostic impact of the type of first medical contact facility.
Rev Esp Cardiol (Engl Ed)
September 2023
Article Synopsis
- The study examines the impact of different types of first medical contact (FMC), such as EMS, community hospital, PCI hospital, and primary care center, on mortality rates in STEMI patients undergoing primary coronary intervention between 2010-2020.
- Out of 18,332 patients, those who received care at PCI hospitals and community hospitals showed higher 1-year mortality rates, while patients at primary care centers had better outcomes despite longer delays in treatment.
- The findings suggest that receiving first medical assistance from PCI and community hospitals may lead to worse survival rates compared to emergency medical services, while primary care centers presented a lower risk and better results overall.
Article Synopsis
- MicroRNAs (miRNAs) play a crucial role in regulating communication between cells and are significant in cardiovascular diseases, especially in patients with acute myocardial infarction (AMI).
- The study analyzed miRNA expression using a cohort of 53 AMI patients (NSTEMI) compared to 51 healthy controls, finding that 58 miRNAs were differentially expressed during AMI and 36 showed changes at a 1-year follow-up.
- Results indicated that during AMI, miRNAs were mainly linked to vascular development processes, while a year later, expression changes were related to cardiac tissue morphogenesis, with let-7e-5p specifically influencing endothelial function and vascularization.
Background: Acute kidney injury (AKI) is frequent in Coronavirus Infection Disease 2019 (COVID-19) patients. Factors associated with AKI in COVID-19 intensive care unit (ICU) patients and their outcomes have not been previously explored.
Methods: Prospective observational study of COVID-19 patients admitted to the ICUs of the Hospital Clínic of Barcelona (Spain), from March 25th to April 21st, 2020, who developed AKI stage 2 or higher (AKIN classification).
Introduction: Infection remains a major complication among heart transplant (HT) recipients, causing approximately 20% of deaths in the first year after transplantation. In this population, Aspergillus species can have various clinical presentations including invasive pulmonary aspergillosis (IPA), which has high mortality (53-78%).
Aims: To establish the characteristics of IPA infection in HT recipients and their outcomes in our setting.
Background: Sex differences in coronary artery disease presentation and outcomes have been described. The aim of this study was to compare sex disparities in chronic total occlusion (CTO) management and long-term outcomes.
Methods: All consecutive patients with at least one CTO diagnosed in our center between 2010 and 2014 were included.
Background: Intermittent renal replacement therapy (IRRT) is prescribed across intensive care units (ICU) worldwide. While research regarding the prescribed dialysis dose has not yielded results concerning mortality, it is still unknown whether the same applies to the actual delivered dose.
Methods: We retrospectively analyzed two different cohorts of patients (562 IRRT sessions) who were admitted to the intensive care units at Hospital Clínic of Barcelona and required renal replacement therapy with IRRT.
Background: Little information exists about the role of anemia in patients with acute coronary syndromes (ACS) admitted to Intensive Cardiac Care Units (ICCU). The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical setting.
Methods: All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS (NSTEACS) were prospectively included.
Although older adults are the fastest-growing age group among cardiovascular patients, nonagenarians with ST-segment elevation myocardial infarction (STEMI) are under-represented in clinical trials. The aims of this study are to analyze the clinical presentation and outcomes of nonagenarian patients presenting with STEMI and to compare in-hospital and 1-year clinical outcomes between those treated with optimal medical treatment alone and those receiving primary percutaneous coronary intervention (pPCI). We included all consecutive nonagenarians presenting with STEMI admitted in 2 academic centers between 2006 and 2018.
View Article and Find Full Text PDFIntroduction: Despite the use of the new generation P2Y12 inhibitors (Ticagrelor and Prasugrel) with aspirin is the recommended therapy in acute NSTE-ACS patients, their current use in clinical practice remains quite low and might be related, among several variables, with increased comorbidity burden. We aimed to assess the prevalence of these treatments and whether their use could be associated with comorbidity.
Method: A multicentric prospective registry was conducted at 8 Cardiac Intensive Care Units (October 2017-April 2018) in patients admitted with non ST elevation myocardial infarction.
Introduction: Infection remains a major complication among heart transplant (HT) recipients, causing approximately 20% of deaths in the first year after transplantation. In this population, Aspergillus spp. can have various clinical presentations including invasive pulmonary aspergillosis (IPA), with high mortality (53-78%).
View Article and Find Full Text PDFRole of coronary angiography in patients with a non-diagnostic electrocardiogram following out of hospital cardiac arrest: Rationale and design of the multicentre randomized controlled COUPE trial.
Eur Heart J Acute Cardiovasc Care
November 2020
Background: Coronary artery disease (CAD) is a major cause of out-of-hospital cardiac arrest (OHCA). The role of emergency coronary angiography (CAG) and percutaneous coronary intervention (PCI) following cardiac arrest in patients without ST-segment elevation myocardial infarction (STEMI) remains unclear.
Aims: We aim to assess whether emergency CAG and PCI, when indicated, will improve survival with good neurological outcome in post-OHCA patients without STEMI who remain comatose.
Background: Chronic total occlusions (CTOs) are present in more than one third of older patients with myocardial ischemia, but controversy remains about the best therapeutic approach.
Aims: To compare long-term survival after CTO revascularization (percutaneous coronary intervention [PCI] or coronary artery bypass graft [CABG]) versus medical treatment (MT) alone in patients aged 75 and older.
Methods And Results: A total of 1,252 consecutive patients with at least one CTO were identified from 2010 to 2014 in our center.