Background: Risks associated with contraindicated drug-drug interaction alerts (CDDIAs) should always outweigh benefits. Misclassified CDDIAs should be eliminated.
Objective: To review CDDIAs and determine if they are contraindicated according to Food and Drug Administration-approved product labeling and if there are circumstances in which contraindicated interactions are acceptable.
Purpose: The publication rates and characteristics of residency projects presented at the Southeastern Residency Conference (SERC) in 1981, 1991, and 2001 are described.
Methods: SERC abstracts from 1981, 1991, and 2001 were searched in MEDLINE and International Pharmaceutical Abstracts with a time limit of six years after the conference. All potential positive publications were reviewed and validated by a second investigator.
Background: Oral phenylephrine is used as a decongestant, yet there has been no previously published systematic review supporting its efficacy and safety.
Objective: To assess the efficacy and safety of oral phenylephrine as a nonprescription decongestant.
Methods: MEDLINE, the Cochrane Central Registry of Controlled Trials, EMBASE, International Pharmaceutical Abstracts, and the Federal Register were searched for English and non-English-language studies published through January 2007 that measured the effects of oral phenylephrine on nasal airway resistance (NAR) in patients with nasal congestion.