Predicting the dissolution rate constant of mineral wool fibers from fiber composition.

Objective: We developed predictive formulae for the dissolution rate constant k of acid-soluble synthetic vitreous fibers (SVF), paralleling our earlier work with glass wools, which are typically more soluble at neutral pH. Developing simple models for predicting the k of a fiber can allow prediction of behavior, aid fiber developers, and potentially reduce testing.

Methods: The k of several acid-soluble SVF were determined using high simulant fluid flow/fiber surface area (F/A) conditions a single-fiber measurement system.

The effect of a new formaldehyde-free binder on the dissolution rate of glass wool fibre in physiological saline solution.

The in-vitro dissolution rate of fibres is a good predictor of the in-vivo behavior and potential health effects of inhaled fibres. This study examines the effect of a new formaldehyde-free carbohydrate-polycarboxylic acid binder on the in-vitro dissolution rate of biosoluble glass fibres. Dissolution rate measurements in pH 7.

The role of fiber durability/biopersistence of silica-based synthetic vitreous fibers and their influence on toxicology.

This work summarizes what is known about the role of fiber durability/biopersistence of silica-based synthetic vitreous fibers (SVFs) and their influence on toxicology. The article describes the key processes leading from exposure to biological effect, including exposure, pulmonary deposition, clearance by various mechanisms, accumulation in the lung, and finally possible biological effects. The dose-dimension-durability paradigm is used to explain the key determinants of SVF toxicology.